14714-50-2

Basic information

• Product Name: (2-Hydroxyphenyl)acetonitrile
• Synonyms: (2-Hydroxyphenyl)acetonitrile;2-(2-hydroxyphenyl)acetonitrile
• CAS NO: 14714-50-2
• Molecular Formula: C₈H₇NO
• Molecular Weight: 133.14728
• Mol File: 14714-50-2.mol
• Article Data: 27

Chemical Properties

• Melting Point: 122-123℃
• Boiling Point: 285.2±15.0℃ (760 Torr)
• Flash Point: 126.3±20.4℃
• Appearance: /
• Density: 1.167±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 9.46±0.30(Predicted)
• CAS DataBase Reference: (2-Hydroxyphenyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Hydroxyphenyl)acetonitrile(14714-50-2)
• EPA Substance Registry System: (2-Hydroxyphenyl)acetonitrile(14714-50-2)

Safety Data

• Hazardous Substances Data: 14714-50-2(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 41, p. 2502, 1976 DOI: 10.1021/jo00876a038

Upstream product

• 704-65-4 2-(bromomethyl)phenyl acetate 
• 143-33-9 sodium cyanide 
• 325141-71-7 [2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetonitrile 
• 69-72-7 salicylic acid 
• 773837-37-9 sodium cyanide 
• 90-01-7 salicylic alcohol 
• 7035-03-2 2-methoxy-benzeneacetonitrile 
• 1058648-87-5 2-[(methoxymethoxy)methyl]phenol 
• 10442-39-4 tetra-n-butylammonium cyanide 
• 1058648-91-1 2-[(ethoxymethoxy)methyl]phenol 
• 40053-98-3 o-chloromethyl phenol 
• 610-66-2 2-nitro-benzeneacetonitrile 
• 346433-42-9 carbonic acid tert-butyl ester 2-formyl-phenyl ester 
• 89-95-2 2-methyl-benzyl alcohol 

Downstream Products

• 106474-17-3 2-(2-hydroxy-phenyl)-3-oxo-3-phenyl-propionitrile 
• 850143-29-2 (2-tetradecyloxyphenyl)acetonitrile 
• 1329116-28-0 3-(3-chlorophenyl)-2H-chromene-4-carbonitrile 
• 1329116-27-9 3-(4-(trifluoromethyl)phenyl)-2H-chromene-4-carbonitrile 
• 1329116-29-1 3-(2,4-difluorophenyl)-2H-chromene-4-carbonitrile 
• 1329116-24-6 3-(4-tolyl)-2H-chromene-4-carbonitrile 
• 1329116-25-7 3-(4-chlorophenyl)-2H-chromene-4-carbonitrile 
• 1329116-26-8 3-(4-fluorophenyl)-2H-chromene-4-carbonitrile 
• 1329116-23-5 3-(4-methoxyphenyl)-2H-chromene-4-carbonitrile 
• 1329116-31-5 2,3-diphenyl-2H-chromene-4-carbonitrile 
• 1374299-71-4 2-(cyanomethyl)phenyl 1-pyrrolidinecarboxylate 
• 1374299-72-5 2-(cyanomethyl)phenyl 4-morpholinecarboxylate 
• 1374299-70-3 2-(cyanomethyl)phenyl 1-piperidinecarboxylate 
• 1374299-83-8 C₁₆H₁₃NO₃ 

Relevant articles and documents

Controlled meta-Selective C-H Mono- And Di-Olefination of Mandelic Acid Derivatives

Mandelic acids represent a key structural motif present in many drug molecules. Herein, we report the controlled meta-selective mono- and diolefination of mandelic acids by the careful design of the substrate and oxidant. Furthermore, free meta-functional

Probing the Existence of a Metastable Binding Site at the β2-Adrenergic Receptor with Homobivalent Bitopic Ligands

Herein, we report the development of bitopic ligands aimed at targeting the orthosteric binding site (OBS) and a metastable binding site (MBS) within the same receptor unit. Previous molecular dynamics studies on ligand binding to the β2-adrenergic receptor (β2AR) suggested that ligands pause at transient, less-conserved MBSs. We envisioned that MBSs can be regarded as allosteric binding sites and targeted by homobivalent bitopic ligands linking two identical pharmacophores. Such ligands were designed based on docking of the antagonist (S)-alprenolol into the OBS and an MBS and synthesized. Pharmacological characterization revealed ligands with similar potency and affinity, slightly increased β2/β1AR-selectivity, and/or substantially slower β2AR off-rates compared to (S)-alprenolol. Truncated bitopic ligands suggested the major contribution of the metastable pharmacophore to be a hydrophobic interaction with the β2AR, while the linkers alone decreased the potency of the orthosteric fragment. Altogether, the study underlines the potential of targeting MBSs for improving the pharmacological profiles of ligands.

Novel organic compounds derivatives and organic light-emitting diode therewith

The present invention relates to an organic compound represented by the chemical formula (A) or (B) and to an organic light-emitting device comprising the same. In the chemical formulas (A) and (B), R_1 to R_14, L1, L2, Ar1 to Ar3, n and m are as described in detailed description of the invention. The first object of the present invention is to provide the organic compound having a specific structure capable of having high efficiency, low voltage and long life characteristics by using the compound in an electron transporting layer or a hole transporting layer in the organic light emitting device.COPYRIGHT KIPO 2018