cyclopropanesulfonic acid [6-chloro-4,4-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-8-carbonyl]-amide

Base Information

Chemical Name:cyclopropanesulfonic acid [6-chloro-4,4-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-8-carbonyl]-amide
CAS No.:1391610-18-6
Molecular Formula:C₂₅H₃₀ClN₃O₄S
Molecular Weight:504.05
Hs Code.:

Synonyms:cyclopropanesulfonic acid [6-chloro-4,4-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-8-carbonyl]-amide

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Chemical Property of cyclopropanesulfonic acid [6-chloro-4,4-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-8-carbonyl]-amide

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Technology Process of cyclopropanesulfonic acid [6-chloro-4,4-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-8-carbonyl]-amide

There total 4 articles about cyclopropanesulfonic acid [6-chloro-4,4-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-8-carbonyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

: 154350-29-5
cyclopropanesulphonamide

: 1391610-17-5
6-chloro-4,4-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-8-carboxylic acid

: 1391610-18-6
cyclopropanesulfonic acid [6-chloro-4,4-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-8-carbonyl]-amide

Guidance literature:: cyclopropanesulphonamide; With sodium hydride; In N,N-dimethyl-formamide; at 25 ℃; for 1h;

6-chloro-4,4-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-8-carboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 25 - 70 ℃; for 2h;

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 1391610-18-6
cyclopropanesulfonic acid [6-chloro-4,4-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-8-carbonyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ytterbium(III) trifluoromethanesulfonate hydrate / acetonitrile / 12 h / 90 °C / sealed reaction bottle

2.1: potassium carbonate; copper(l) iodide; N,N-dimethylglycine hydrochoride / dimethyl sulfoxide / 16 h / 120 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 25 °C

3.2: 2 h / 25 - 70 °C

With copper(l) iodide; ytterbium(III) trifluoromethanesulfonate hydrate; N,N-dimethylglycine hydrochoride; sodium hydride; potassium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1373546-27-0
2-(3-bromo-phenyl)-6-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-8-carboxylic acid methyl ester

: 1391610-18-6
cyclopropanesulfonic acid [6-chloro-4,4-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-8-carbonyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate; copper(l) iodide; N,N-dimethylglycine hydrochoride / dimethyl sulfoxide / 16 h / 120 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 25 °C

2.2: 2 h / 25 - 70 °C

With copper(l) iodide; N,N-dimethylglycine hydrochoride; sodium hydride; potassium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide;