({3-[(3-bromo-5-chlorophenyl)oxy]-4-chloro-2-fluorophenyl}methyl)amine

Base Information

Chemical Name:({3-[(3-bromo-5-chlorophenyl)oxy]-4-chloro-2-fluorophenyl}methyl)amine
CAS No.:1093262-88-4
Molecular Formula:C₁₃H₉BrCl₂FNO
Molecular Weight:365.029
Hs Code.:

Synonyms:({3-[(3-bromo-5-chlorophenyl)oxy]-4-chloro-2-fluorophenyl}methyl)amine

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Chemical Property of ({3-[(3-bromo-5-chlorophenyl)oxy]-4-chloro-2-fluorophenyl}methyl)amine

Chemical Property:

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Technology Process of ({3-[(3-bromo-5-chlorophenyl)oxy]-4-chloro-2-fluorophenyl}methyl)amine

There total 7 articles about ({3-[(3-bromo-5-chlorophenyl)oxy]-4-chloro-2-fluorophenyl}methyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1093262-86-2
2-[(3-bromo-5-chlorophenyl)oxy]-4-(bromomethyl)-1-chloro-3-fluorobenzene

: 1093262-88-4
({3-[(3-bromo-5-chlorophenyl)oxy]-4-chloro-2-fluorophenyl}methyl)amine

Guidance literature:: With ammonia; In methanol; dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 1093267-98-1
2-[(3-bromo-5-chlorophenyl)oxy]-3,4-difluoro-1-nitrobenzene

: 1093262-88-4
({3-[(3-bromo-5-chlorophenyl)oxy]-4-chloro-2-fluorophenyl}methyl)amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: 1.5 h / 0 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 3 h / 40 °C

3.1: copper(I) oxide / acetonitrile / 3 h / Reflux

4.1: sodium dithionite / tetrahydrofuran; water / 16 h / 40 °C

5.1: tert.-butylnitrite; copper dichloride / acetonitrile / 0.5 h / 50 °C / Inert atmosphere

6.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 6 h / 90 °C / Inert atmosphere

7.1: ammonia / methanol; dichloromethane / 4 h / 20 °C

With copper(I) oxide; N-Bromosuccinimide; tert.-butylnitrite; sodium dithionite; 2,2'-azobis(isobutyronitrile); ammonia; sodium hydride; trifluoroacetic acid; copper dichloride; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; acetonitrile;

Reference yield:

: 1093262-77-1
bis(1,1-dimethylethyl) {3-[(3-bromo-5-chlorophenyl)oxy]-2-fluoro-4-nitrophenyl}propanedioate

: 1093262-88-4
({3-[(3-bromo-5-chlorophenyl)oxy]-4-chloro-2-fluorophenyl}methyl)amine

Guidance literature:: Multi-step reaction with 6 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 40 °C

2: copper(I) oxide / acetonitrile / 3 h / Reflux

3: sodium dithionite / tetrahydrofuran; water / 16 h / 40 °C

4: tert.-butylnitrite; copper dichloride / acetonitrile / 0.5 h / 50 °C / Inert atmosphere

5: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 6 h / 90 °C / Inert atmosphere

6: ammonia / methanol; dichloromethane / 4 h / 20 °C

With copper(I) oxide; N-Bromosuccinimide; tert.-butylnitrite; sodium dithionite; 2,2'-azobis(isobutyronitrile); ammonia; trifluoroacetic acid; copper dichloride; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; acetonitrile;