[(S)-4-Hydroxy-4-(methoxy-methyl-carbamoyl)-butyl]-carbamic acid benzyl ester

Base Information

Chemical Name:[(S)-4-Hydroxy-4-(methoxy-methyl-carbamoyl)-butyl]-carbamic acid benzyl ester
CAS No.:330798-19-1
Molecular Formula:C₁₅H₂₂N₂O₅
Molecular Weight:310.35
Hs Code.:

Synonyms:[(S)-4-Hydroxy-4-(methoxy-methyl-carbamoyl)-butyl]-carbamic acid benzyl ester

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Chemical Property of [(S)-4-Hydroxy-4-(methoxy-methyl-carbamoyl)-butyl]-carbamic acid benzyl ester

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Technology Process of [(S)-4-Hydroxy-4-(methoxy-methyl-carbamoyl)-butyl]-carbamic acid benzyl ester

There total 6 articles about [(S)-4-Hydroxy-4-(methoxy-methyl-carbamoyl)-butyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 50721-37-4
S-5-benzyloxycarbonylamino-2-hydroxypentanoic acid

: 330798-19-1
[(S)-4-Hydroxy-4-(methoxy-methyl-carbamoyl)-butyl]-carbamic acid benzyl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jo001297m

Reference yield:

: (S)-5-Azido-2-hydroxy-pentanoic acid methoxy-methyl-amide

: 330798-19-1
[(S)-4-Hydroxy-4-(methoxy-methyl-carbamoyl)-butyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂; aq.HCl / Pd/C / ethanol / 3 h / 7600.51 Torr

2: NaHCO₃ / tetrahydrofuran; H₂O / 1 h / 0 °C

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; ethanol; water;
DOI:10.1021/jo001297m

Reference yield:

: 2-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-pentanoic acid methoxy-methyl-amide

: 330798-19-1
[(S)-4-Hydroxy-4-(methoxy-methyl-carbamoyl)-butyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: aq. HCl / tetrahydrofuran / 5 h / 20 °C

2: triphenylphosphine; diphenylphosphoryl azide; DEAD / tetrahydrofuran / 1 h / 20 °C

3: H₂; aq.HCl / Pd/C / ethanol / 3 h / 7600.51 Torr

4: NaHCO₃ / tetrahydrofuran; H₂O / 1 h / 0 °C

With hydrogenchloride; diphenylphosphoranyl azide; hydrogen; sodium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; 2: Mitsunobu reaction;
DOI:10.1021/jo001297m