(S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(4,5-diiodo-1H-imidazol-2-yl)heptanoate

Base Information

Chemical Name:(S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(4,5-diiodo-1H-imidazol-2-yl)heptanoate
CAS No.:1609191-06-1
Molecular Formula:C₂₂H₂₉I₂N₃O₄
Molecular Weight:653.299
Hs Code.:

Synonyms:(S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(4,5-diiodo-1H-imidazol-2-yl)heptanoate

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Chemical Property of (S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(4,5-diiodo-1H-imidazol-2-yl)heptanoate

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Technology Process of (S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(4,5-diiodo-1H-imidazol-2-yl)heptanoate

There total 4 articles about (S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(4,5-diiodo-1H-imidazol-2-yl)heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1609191-04-9
⁽⁵⁾-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(1H-imidazol-2-yl)heptanoate

: 1609191-06-1
(S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(4,5-diiodo-1H-imidazol-2-yl)heptanoate

Guidance literature:: With N-iodo-succinimide; In acetonitrile; at -10 ℃;
DOI:10.1021/acsmedchemlett.5b00468

Reference yield:

: 1609191-03-8
(S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-8-oxooctanoate

: 1609191-06-1
(S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(4,5-diiodo-1H-imidazol-2-yl)heptanoate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia / methanol / 72 h / 20 °C / Sealed tube

2: N-iodo-succinimide / acetonitrile / 2 h / -10 °C

With N-iodo-succinimide; ammonia; In methanol; acetonitrile;

Reference yield:

: 49645-27-4
(S)-2-(((benzyloxy)carbonyl)amino)-8-(tert-butoxy)-8-oxooctanoic acid

: 1609191-06-1
(S)-tert-butyl 7-(((benzyloxy)carbonyl)amino)-7-(4,5-diiodo-1H-imidazol-2-yl)heptanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 16 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / -20 °C

3.1: ammonia / methanol / 72 h / 20 °C / Sealed tube

4.1: N-iodo-succinimide / acetonitrile / 2 h / -10 °C

With N-iodo-succinimide; lithium aluminium tetrahydride; ammonia; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;