8-amino-7-phenyl-9,10,11,12-tetrahydrochromeno[3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one

Base Information

• Chemical Name: 8-amino-7-phenyl-9,10,11,12-tetrahydrochromeno[3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one
• CAS No.: 1470027-65-6
• Molecular Formula: C₂₅H₂₀N₂O₃
• Molecular Weight: 396.445
• Mol file: 1470027-65-6.mol

Synonyms:8-amino-7-phenyl-9,10,11,12-tetrahydrochromeno[3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one

Chemical Property of 8-amino-7-phenyl-9,10,11,12-tetrahydrochromeno[3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-amino-7-phenyl-9,10,11,12-tetrahydrochromeno[3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one

There total 4 articles about 8-amino-7-phenyl-9,10,11,12-tetrahydrochromeno[3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-amino-5-oxo-4-phenyl-4H,5H-pyrano[3,2-c]chromene-3-carbonitrile (96767-93-0) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 8-amino-7-phenyl-9,10,11,12-tetrahydrochromeno[3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one (1470027-65-6)

Guidance literature:

With aluminum (III) chloride; In 1,2-dichloro-ethane; for 24h; Inert atmosphere; Reflux;

DOI:10.1016/j.ejmech.2013.07.045

Reference yield:

benzaldehyde (100-52-7) → 8-amino-7-phenyl-9,10,11,12-tetrahydrochromeno[3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one (1470027-65-6)

Guidance literature:

Multi-step reaction with 3 steps

1: (2-aminomethyl)phenol moiety on the surface of hydroxyapatite encapsulated maghemite (γ-Fe₂O₃) / water / 0.08 h / Reflux

2: (2-aminomethyl)phenol moiety on the surface of hydroxyapatite encapsulated maghemite (γ-Fe₂O₃) / water / Reflux

3: aluminum (III) chloride / 1,2-dichloro-ethane / 24 h / Inert atmosphere; Reflux

With aluminum (III) chloride; In water; 1,2-dichloro-ethane; 3: |Friedlaender Quinoline Synthesis;

DOI:10.1016/j.ejmech.2013.07.045

Reference yield:

4-hydroxy[1]benzopyran-2-one (1076-38-6,92395-12-5) → 8-amino-7-phenyl-9,10,11,12-tetrahydrochromeno[3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one (1470027-65-6)

Guidance literature:

Multi-step reaction with 2 steps

1: silica sodium carbonate / neat (no solvent) / 110 °C

2: sodium carbonate / dimethyl sulfoxide / 7 h / 100 °C

With sodium carbonate; In dimethyl sulfoxide;

DOI:10.17344/acsi.2020.6266

upstream raw materials:

Benzylidenemalononitrile

2-amino-5-oxo-4-phenyl-4H,5H-pyrano[3,2-c]chromene-3-carbonitrile

cyclohexanone

benzaldehyde