96767-93-0

Upstream product

• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 2700-22-3 Benzylidenemalononitrile 
• 91-64-5 coumarin 
• 100-52-7 benzaldehyde 
• 109-77-3 malononitrile 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 100-51-6 benzyl alcohol 
• 22105-09-5 4‐hydroxycoumarin 
• 1330776-87-8 4-hydroxy-3-(phenyl(pyrrolidin-1-yl)methyl)-2H-chromen-2-one 
• 100-39-0 benzyl bromide 

Downstream Products

• 1470027-65-6 8-amino-7-phenyl-9,10,11,12-tetrahydrochromeno[3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one 
• 4958-06-9 3-(4–hydroxy-2-oxo-2H-chromen-3-yl)?3-phenylpropanoic acid 

Relevant academic research and scientific papers

An efficient and one-pot green synthesis of novel 6-oxo-7-aryl-6,7-dihydrochromeno pyrano[2,3-b]pyridine derivatives

A simple and efficient protocol has been developed for the construction of novel 6-oxo-7-aryl-6,7-dihydrochromenopyrano[2,3-b]pyridine derivatives using one-pot, three-component cyclocondensation of 4-hydroxycoumarin, various aromatic aldehydes and 2-amin

Green synthesis of dihydropyrano[3,2-c]chromene derivatives using amino-terminated PAMAM dendrimer as catalyst

d-Sorbitol-cored PAMAM dendrimer (SOR-G1) was effectively synthesized by the ring opening polymerization of epichlorohydrin. The dendrimer was characterized using different spectroscopic and analytical techniques including IR and NMR spectroscopy, TG–DTA,

Tertiary amine-bisquaternary ammonium functionalized polyacrylonitrile fiber for catalytic synthesis of pyran-annulated heterocycles

Polyacrylonitrile fiber supported bisquaternary ammonium salts with varying interchain quaternary ammonium (QA) to tertiary amine (TA) ratio, counter ions and linker groups were prepared and characterized by TGA, FTIR, XPS, XRD, SEM, EA and water contact

Rational design, synthesis and SAR study of novel warfarin analogous of 4-hydroxy coumarin-beta-aryl propanoic acid derivatives as potent anti-inflammatory agents

Synthesis of highly potent and enhanced safety profiled antiinflammatory drugs has become a challenging task in the drug discovery process. A library of warfarin analogue 3-(4?hydroxy-2-oxo-2H-chromen-3-yl)-3-arylpropanoic acid derivatives have been synthesised and their structures were established by availing different analysis techniques. The invitro COX-1/COX-2 study revealed the effective potency of the selective compounds 2b(IC50=180.45 μl/ml), 2c(IC50=21.03 μl/ml) and 2f(IC50=120.45 μl/ml) against COX-2 compared to reference drug aspirin (IC50=121.60 μl/ml). Compound 2c is more selective towards COX-2 with a high selective index of 7.42 than standard aspirin with a selective index of 4.14. Further, the target molecules were assessed for their antiinflammatory activity against MMP2 and MMP9, the results revealing a high percentage of inhibition. While, protein denaturation study displayed high potency of the compounds 2a (IC50=13.32 μg/ml), 2 g (IC50=11.14 μg/ml) and 2l (IC50=4.71 μg/ml) as compared with aspirin (IC50=13.42 μl/ml). The docking studies were established to understand the structural features responsible for biological activity and the outcome of the docking studies are indeed following the experimental results.

Synthesis of Fe3O4-supported Schiff base Cu (II) complex: a novel efficient and recyclable magnetic nanocatalyst for one-pot three-component synthesis of quinolin-5-one, chromene-3-carbonitrile and phthalazine-5,10-dione derivatives

In this research, synthesis and characterization of a novel Schiff base Cu (II) complex immobilized on Fe3O4@SiO2 nanoparticles are reported. Then, the catalytic activity of these nanoparticles as magnetic recyclable nanocatalyst was explored for the one-pot three-component synthesis of quinolin-5-one, chromene-3-carbonitrile and phthalazine-5,10-dione derivatives. The reactions proceeded smoothly to provide the respective products in excellent yields under green conditions. Facile preparation of the catalyst, high yields of the products, low reaction times, and use of water as green solvent are the main advantages of the present protocol. Moreover, the catalyst can be easily separated from the reaction mixture in a magnetic field, recycled and reused for six consecutive fresh runs without considerable loss of catalytic activity. Graphic abstract: [Figure not available: see fulltext.]

Solvent-free synthesis of compounds containing chromene core catalyzed by novel Br?nsted acidic ionic liquids-ClO4

A series of novel sulfonic acid-functionalized Br?nsted acidic ionic liquids (BAILs) with perchlorate counter anion are introduced. These ionic liquid catalysts were prepared through simple and eco-friendly procedures in high yields. Various analytical te

Zr@IL-Fe3O4MNPs as an efficient and green heterogeneous magnetic nanocatalyst for the one-pot three-component synthesis of highly substituted pyran derivatives under solvent-free conditions

The present study was conducted to synthesize Zr@IL-Fe3O4MNPs as a new magnetically recoverable heterogeneous catalyst, which was then characterized by Fourier transform infrared (FT-IR) spectroscopy, energy dispersive X-ray spectros

One‐pot and green synthesis 1H-pyrazolo[1,2-b]phthalazine-5,10-dione and dihydropyrano[3,2-c]chromene derivatives by Fe3O4@SiO2-imine/phenoxy-Cu(II) as an efficient and reusable catalyst

In the current study, magnetite-silica core–shell nanoparticles modified with Cu-salen complex (Fe3O4@SiO2-imine/phenoxy-Cu(II)) was utilized as a heterogeneous catalyst for the one-pot multicomponent synthesis of 1H-pyraz

New advances in catalytic performance of erbium-folic acid-coated CoFe2O4 complexes for green one-pot three-component synthesis of pyrano[2,3-d]pyrimidinone and dihydropyrano[3,2-c]chromenes compounds in water

In the current research, much attention is paid to heterogenized nanostructure. Herein, we report the green synthesis magnetic nanoparticles (MNPs) of cobalt ferrite by the immobilization of erbium (Er) coated with folic acid (FA) which show effective cat

A synergetic role of Aegle marmelos fruit ash in the synthesis of biscoumarins and 2-amino-4H-chromenes

Abstract: A dry rind of Aegle marmelos (bael) fruit ash as a synergetic alternative material to an expensive, toxic and corrosive catalysts for the synthesis of biscoumarins and 2-amino-4H-chromenes at ambient temperature in water is reported. The spectro