Technology Process of (S)-3-(tert-butyldimethylsilylyloxy)-3-phenylpropan-1-ol
There total 5 articles about (S)-3-(tert-butyldimethylsilylyloxy)-3-phenylpropan-1-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(tert-butyl)(dimethyl){[(1S)-1-phenylprop-2-en-1-yl]oxy}silane;
With
dimethylsulfide borane complex;
In
tetrahydrofuran;
at 0 ℃;
for 2h;
With
dihydrogen peroxide;
In
tetrahydrofuran; water;
at 0 ℃;
for 3.5h;
DOI:10.1016/j.tetasy.2013.06.003
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: Prunus armeniaca hydroxynitrile lyase / di-isopropyl ether / 10 °C / pH 4 / Enzymatic reaction
2.1: 1H-imidazole; dmap / dichloromethane / 6 h / 0 - 20 °C
3.1: diisobutylaluminium hydride / dichloromethane / 1 h / -45 °C / Inert atmosphere
4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / 0 °C
4.2: 1 h / 20 °C
5.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 0 °C
5.2: 3.5 h / 0 °C
With
1H-imidazole; dmap; dimethylsulfide borane complex; Prunus armeniaca hydroxynitrile lyase; diisobutylaluminium hydride; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; di-isopropyl ether;
4.1: |Wittig Olefination / 4.2: |Wittig Olefination;
DOI:10.1016/j.tetasy.2013.06.003
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 1H-imidazole; dmap / dichloromethane / 6 h / 0 - 20 °C
2.1: diisobutylaluminium hydride / dichloromethane / 1 h / -45 °C / Inert atmosphere
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / 0 °C
3.2: 1 h / 20 °C
4.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 0 °C
4.2: 3.5 h / 0 °C
With
1H-imidazole; dmap; dimethylsulfide borane complex; diisobutylaluminium hydride; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane;
3.1: |Wittig Olefination / 3.2: |Wittig Olefination;
DOI:10.1016/j.tetasy.2013.06.003
