(S)-3-(tert-butyldimethylsilyloxy)-N-methyl-3-phenylpropan-1-amine

Base Information

Chemical Name:(S)-3-(tert-butyldimethylsilyloxy)-N-methyl-3-phenylpropan-1-amine
CAS No.:1453857-68-5
Molecular Formula:C₁₆H₂₉NOSi
Molecular Weight:279.498
Hs Code.:

Synonyms:(S)-3-(tert-butyldimethylsilyloxy)-N-methyl-3-phenylpropan-1-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-(tert-butyldimethylsilyloxy)-N-methyl-3-phenylpropan-1-amine

Chemical Property:

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Technology Process of (S)-3-(tert-butyldimethylsilyloxy)-N-methyl-3-phenylpropan-1-amine

There total 7 articles about (S)-3-(tert-butyldimethylsilyloxy)-N-methyl-3-phenylpropan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1453857-66-3
(S)-3-(tert-butyldimethylsilyloxy)-3-phenylpropyl methanesulfonate

: 74-89-5
methylamine

: 1453857-68-5
(S)-3-(tert-butyldimethylsilyloxy)-N-methyl-3-phenylpropan-1-amine

Guidance literature:: In tetrahydrofuran; water; at 65 ℃; for 3h;
DOI:10.1016/j.tetasy.2013.06.003

Reference yield:

: 100-52-7
benzaldehyde

: 1453857-68-5
(S)-3-(tert-butyldimethylsilyloxy)-N-methyl-3-phenylpropan-1-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: Prunus armeniaca hydroxynitrile lyase / di-isopropyl ether / 10 °C / pH 4 / Enzymatic reaction

2.1: 1H-imidazole; dmap / dichloromethane / 6 h / 0 - 20 °C

3.1: diisobutylaluminium hydride / dichloromethane / 1 h / -45 °C / Inert atmosphere

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / 0 °C

4.2: 1 h / 20 °C

5.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 0 °C

5.2: 3.5 h / 0 °C

6.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

7.1: water; tetrahydrofuran / 3 h / 65 °C

With 1H-imidazole; dmap; dimethylsulfide borane complex; Prunus armeniaca hydroxynitrile lyase; diisobutylaluminium hydride; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; di-isopropyl ether; water; 4.1: |Wittig Olefination / 4.2: |Wittig Olefination;
DOI:10.1016/j.tetasy.2013.06.003

Reference yield:

: 1453857-64-1
(S)-3-(tert-butyldimethylsilylyloxy)-3-phenylpropan-1-ol

: 1453857-68-5
(S)-3-(tert-butyldimethylsilyloxy)-N-methyl-3-phenylpropan-1-amine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

2: water; tetrahydrofuran / 3 h / 65 °C

With triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tetasy.2013.06.003