Chemical Property of 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide
Chemical Property:
- Vapor Pressure:1.38E-10mmHg at 25°C
- Melting Point:74-75
- Refractive Index:1.611
- Boiling Point:511.7°C at 760 mmHg
- PKA:1.76±0.50(Predicted)
- Flash Point:263.3°C
- PSA：33.20000
- Density:1.179g/cm3
- LogP:5.42570
- Storage Temp.:Store at RT
- Solubility.:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml).
- XLogP3:5.5
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:4
- Exact Mass:352.1342410
- Heavy Atom Count:25
- Complexity:457
- Purity/Quality:
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98%,99%, *data from raw suppliers
PK 11195 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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Useful:
- Canonical SMILES:CCC(C)N(C)C(=O)C1=CC2=CC=CC=C2C(=N1)C3=CC=CC=C3Cl
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Description
PK-11195 (85532-75-8) is a selective and potent peripheral benzodiazepine receptor, PBR (or TSPO, translocator protein) antagonist.1,2 It has been shown to chemosensitize tumor cells to a variety of chemotherapeutic agents via PBR-independent pathways.3,4 PK-11195 is also able to induce apoptosis in a variety of cell lines.5-7
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Uses
PK 11195 is a high affinity peripheral benzodiazepine receptor (PBR) ligand. PK 11195 has been shown to regulate protein phosphorylation in rat brain mitochondria under control of Ca2+. PK11195 promot
es mitochondrial apoptosis and blocks P-glycoprotein (Pgp)-mediated drug efflux to chemosensitize cancer cells. PK 11195 is a high affinity peripheral benzodiazepine receptor (PBR) ligand. PK 11195 has been shown to regulate protein phosphorylation in rat brain mitochondria under control of Ca2+. PK11195 promotes mitochondrial apoptosis and blocks P-glycoprotein (Pgp)-mediated drug efflux to chemosensitize cancer cells.
