2-(3,4-Dichloro-phenyl)-1-((R)-2-pyrrolidin-1-ylmethyl-piperidin-1-yl)-ethanone

Base Information

Chemical Name:2-(3,4-Dichloro-phenyl)-1-((R)-2-pyrrolidin-1-ylmethyl-piperidin-1-yl)-ethanone
CAS No.:130497-35-7
Molecular Formula:C₁₈H₂₄Cl₂N₂O
Molecular Weight:355.307
Hs Code.:

Synonyms:2-(3,4-Dichloro-phenyl)-1-((R)-2-pyrrolidin-1-ylmethyl-piperidin-1-yl)-ethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(3,4-Dichloro-phenyl)-1-((R)-2-pyrrolidin-1-ylmethyl-piperidin-1-yl)-ethanone

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Technology Process of 2-(3,4-Dichloro-phenyl)-1-((R)-2-pyrrolidin-1-ylmethyl-piperidin-1-yl)-ethanone

There total 15 articles about 2-(3,4-Dichloro-phenyl)-1-((R)-2-pyrrolidin-1-ylmethyl-piperidin-1-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 123-75-1
pyrrolidine

: 125348-92-7
1-<(3,4-dichlorophenyl)acetyl>-2-piperidinecarboxaldehyde

: 128103-41-3,130497-33-5,130497-34-6,130497-35-7
[3H]-BRL 52537

Guidance literature:: With hydrogenchloride; 3 A molecular sieve; sodium cyanoborohydride; In methanol; for 72h; Ambient temperature;
DOI:10.1021/jm00081a009

Reference yield:

: 100158-63-2
2-[(1-Pyrrolidinyl)methyl]piperidine

: 6831-55-6
2-(3,4-dichlorophenyl)acetyl chloride

: 128103-41-3,130497-33-5,130497-34-6,130497-35-7
[3H]-BRL 52537

Guidance literature:: With potassium carbonate; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1021/jm00105a061

Reference yield:

: 5807-30-7
3,4-dichlorophenyl acetic acid

: 128103-41-3,130497-33-5,130497-34-6,130497-35-7
[3H]-BRL 52537

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 1,1'-carbonyldiimidazole / 1.) acetonitrile, RT, 20 min, 2.) acetonitrile, RT, 6 h

2: 69 percent / CrO₃, pyridine / CH₂Cl₂ / 1 h / Ambient temperature

3: 76 percent / 5N HCl, 3-Angstroem molecular sieves, NaBH₃CN / methanol / 72 h / Ambient temperature

With pyridine; chromium(VI) oxide; hydrogenchloride; 3 A molecular sieve; sodium cyanoborohydride; 1,1'-carbonyldiimidazole; In methanol; dichloromethane;
DOI:10.1021/jm00081a009