3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-benzylaminopropionic acid methyl ester

Base Information

Chemical Name:3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-benzylaminopropionic acid methyl ester
CAS No.:939378-15-1
Molecular Formula:C₃₅H₄₉N₂O₆P
Molecular Weight:624.758
Hs Code.:

Synonyms:3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-benzylaminopropionic acid methyl ester

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Chemical Property of 3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-benzylaminopropionic acid methyl ester

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Technology Process of 3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-benzylaminopropionic acid methyl ester

There total 3 articles about 3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-benzylaminopropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 939377-99-8
3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-aminopropionic acid methyl ester

: 100-39-0
benzyl bromide

: 939378-15-1
3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-benzylaminopropionic acid methyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 45 ℃; for 6h;
DOI:10.1016/j.bmc.2007.02.042

Reference yield: 11.0%

: 939377-99-8
3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-aminopropionic acid methyl ester

: 100-39-0
benzyl bromide

: 939378-15-1
3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-benzylaminopropionic acid methyl ester

: C₄₂H₅₅N₂O₆P

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 6h;
DOI:10.1016/j.bmc.2007.02.042

Reference yield:

: 260390-87-2
(1-(N-(tert-butyloxycarbonyl)amino)-3-phenylpropyl) phosphinic acid

: 939378-15-1
3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-benzylaminopropionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / hexamethyldisilazane / Heating

2: 80 percent / silver oxide / CHCl₃ / Heating

3: 100 percent / H₂ / Pd/BaSO₄ / methanol; H₂O / 3.5 h

4: 80 percent / cesium carbonate / dimethylformamide / 6 h / 45 °C

With hydrogen; caesium carbonate; 1,1,1,3,3,3-hexamethyl-disilazane; silver(l) oxide; Pd-BaSO₄; In methanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2007.02.042