N₂-[(benzyloxy)carbonyl]-N₁-[(3S)-2-oxotetrahydrofuran-3-yl]-L-leucinamide

Base Information

Chemical Name:N₂-[(benzyloxy)carbonyl]-N₁-[(3S)-2-oxotetrahydrofuran-3-yl]-L-leucinamide
CAS No.:167766-55-4
Molecular Formula:C₁₈H₂₄N₂O₅
Molecular Weight:348.399
Hs Code.:

N<sub>2</sub>-[(benzyloxy)carbonyl]-N<sub>1</sub>-[(3S)-2-oxotetrahydrofuran-3-yl]-L-leucinamide

Synonyms:N₂-[(benzyloxy)carbonyl]-N₁-[(3S)-2-oxotetrahydrofuran-3-yl]-L-leucinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N₂-[(benzyloxy)carbonyl]-N₁-[(3S)-2-oxotetrahydrofuran-3-yl]-L-leucinamide

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Technology Process of N₂-[(benzyloxy)carbonyl]-N₁-[(3S)-2-oxotetrahydrofuran-3-yl]-L-leucinamide

There total 2 articles about N₂-[(benzyloxy)carbonyl]-N₁-[(3S)-2-oxotetrahydrofuran-3-yl]-L-leucinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 2018-66-8
Z-Leu-OH

: 6305-38-0,15295-77-9,67580-93-2,110045-70-0
(S)-(-)-α-amino-γ-butyrolactone hydrobromide

: 167766-55-4
N₂-[(benzyloxy)carbonyl]-N₁-[(3S)-2-oxotetrahydrofuran-3-yl]-L-leucinamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 15h;

Reference yield: 68.0%

: 2018-66-8
Z-Leu-OH

salt water: salt water

: 3-dimethylaminopropylcarbodiimide monohydrochloride

: 6305-38-0,15295-77-9,67580-93-2,110045-70-0
(S)-(-)-α-amino-γ-butyrolactone hydrobromide

: 167766-55-4
N₂-[(benzyloxy)carbonyl]-N₁-[(3S)-2-oxotetrahydrofuran-3-yl]-L-leucinamide

Guidance literature:: With sodium hydrogencarbonate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; citric acid; In methylbutane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield: 72.0%

: 167766-55-4
N₂-[(benzyloxy)carbonyl]-N₁-[(3S)-2-oxotetrahydrofuran-3-yl]-L-leucinamide

: 201155-19-3
N₂-[(benzyloxy)carbonyl]-N₁-[(3S)-2-hydroxytetrahydrofuran-3-yl]-L-leucinamide

Guidance literature:: N₂-[(benzyloxy)carbonyl]-N₁-[(3S)-2-oxotetrahydrofuran-3-yl]-L-leucinamide; With diisobutylaluminium hydride; In dichloromethane; at -60 ℃; for 0.25h;

With potassium tartrate sodium salt; water; In dichloromethane; for 2h;