[2-(2-hydroxy-ethyl)-6-methoxy-phenyl]-(3-methoxy-phenyl)-methanone

Base Information

Chemical Name:[2-(2-hydroxy-ethyl)-6-methoxy-phenyl]-(3-methoxy-phenyl)-methanone
CAS No.:891829-94-0
Molecular Formula:C₁₇H₁₈O₄
Molecular Weight:286.328
Hs Code.:

Synonyms:[2-(2-hydroxy-ethyl)-6-methoxy-phenyl]-(3-methoxy-phenyl)-methanone

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Chemical Property of [2-(2-hydroxy-ethyl)-6-methoxy-phenyl]-(3-methoxy-phenyl)-methanone

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Technology Process of [2-(2-hydroxy-ethyl)-6-methoxy-phenyl]-(3-methoxy-phenyl)-methanone

There total 1 articles about [2-(2-hydroxy-ethyl)-6-methoxy-phenyl]-(3-methoxy-phenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 30404-50-3
8-methoxy-3,4-dihydroisocoumarin

: 36282-40-3
(3-methoxyphenyl)magnesium bromide

: 891829-94-0
[2-(2-hydroxy-ethyl)-6-methoxy-phenyl]-(3-methoxy-phenyl)-methanone

Guidance literature:: In tetrahydrofuran; dichloromethane; at -78 - 20 ℃;
DOI:10.1021/ol060556c

Reference yield: 100.0%

: 891829-94-0
[2-(2-hydroxy-ethyl)-6-methoxy-phenyl]-(3-methoxy-phenyl)-methanone

: 18162-48-6
tert-butyldimethylsilyl chloride

: 891829-95-1
{2-[2-(tert-butyldimethylsilanyloxy)ethyl]-6-methoxyphenyl}-(3-methoxyphenyl)-methanone

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/ol060556c

Reference yield:

: 891829-94-0
[2-(2-hydroxy-ethyl)-6-methoxy-phenyl]-(3-methoxy-phenyl)-methanone

: (1R,2R)-7-Methoxy-1-(3-methoxy-phenyl)-1-vinyl-indan-2-ylamine

Guidance literature:: Multi-step reaction with 15 steps

1.1: 100 percent / imidazole / CH₂Cl₂ / 2 h / 20 °C

2.1: acetic acid / Heating

3.1: 100 percent / TBAF / tetrahydrofuran / 2 h / 20 °C

4.1: 79 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

5.1: Et₃N; Na₂SO₄ / toluene / 1 h / 20 °C

6.1: toluene / 36 h / 115 °C

7.1: 769 mg / toluene / 24 h / 115 °C

8.1: 94 percent / H₂ / Pd(OH)2/C / CH₂Cl₂; methanol / 12 h / 20 °C / 760 Torr

9.1: 99 percent / imidazole / CH₂Cl₂; dimethylformamide / 12 h / 20 °C

10.1: 100 percent / tetrahydrofuran

11.1: 100 percent / TBAF / tetrahydrofuran

12.1: 97 percent / Dess-Martin periodinane / CH₂Cl₂

13.1: tetrahydrofuran

13.2: 84 percent / BF₃*Et₂O

14.1: 69 percent / K₂CO₃; H₂O / methanol

With 1H-imidazole; tetrabutyl ammonium fluoride; water; hydrogen; potassium carbonate; Dess-Martin periodane; acetic acid; sodium sulfate; triethylamine; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 5.1: Dess-Martin oxidation / 13.1: Dess-Martin oxidation / 14.2: Peterson olefination;
DOI:10.1021/ol060556c