(2S)-2-([{(9H-fluoren-9-yl) methoxy}carbonyl]amino)3-{4-(difluoro[hydroxy{(2-nitro-benzyl)oxy}phosphoryl] methyl)-phenyl}propanoic acid

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Chemical Name:(2S)-2-([{(9H-fluoren-9-yl) methoxy}carbonyl]amino)3-{4-(difluoro[hydroxy{(2-nitro-benzyl)oxy}phosphoryl] methyl)-phenyl}propanoic acid
CAS No.:1609462-55-6
Molecular Formula:C₃₂H₂₇F₂N₂O₉P
Molecular Weight:652.545
Hs Code.:

Synonyms:(2S)-2-([{(9H-fluoren-9-yl) methoxy}carbonyl]amino)3-{4-(difluoro[hydroxy{(2-nitro-benzyl)oxy}phosphoryl] methyl)-phenyl}propanoic acid

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Chemical Property of (2S)-2-([{(9H-fluoren-9-yl) methoxy}carbonyl]amino)3-{4-(difluoro[hydroxy{(2-nitro-benzyl)oxy}phosphoryl] methyl)-phenyl}propanoic acid

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Technology Process of (2S)-2-([{(9H-fluoren-9-yl) methoxy}carbonyl]amino)3-{4-(difluoro[hydroxy{(2-nitro-benzyl)oxy}phosphoryl] methyl)-phenyl}propanoic acid

There total 6 articles about (2S)-2-([{(9H-fluoren-9-yl) methoxy}carbonyl]amino)3-{4-(difluoro[hydroxy{(2-nitro-benzyl)oxy}phosphoryl] methyl)-phenyl}propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609462-52-3
(2S)-allyl 2-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-3-{4-(difluoro[hydroxy{(2-nitrobenzyl)oxy}phosphoryl]methyl)phenyl}propanoate

: 1609462-55-6
(2S)-2-([{(9H-fluoren-9-yl) methoxy}carbonyl]amino)3-{4-(difluoro[hydroxy{(2-nitro-benzyl)oxy}phosphoryl] methyl)-phenyl}propanoic acid

Guidance literature:: (2S)-allyl 2-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-3-{4-(difluoro[hydroxy{(2-nitrobenzyl)oxy}phosphoryl]methyl)phenyl}propanoate; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-methylaniline; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; Inert atmosphere;
DOI:10.1016/j.bmc.2014.04.002

Reference yield:

: 1609462-44-3
(S)-allyl 2-{(tert-butoxycarbonyl)amino}-3-[4-{(diethoxyphosphoryl)difluoromethyl}phenyl]propanoate

: 1609462-55-6
(2S)-2-([{(9H-fluoren-9-yl) methoxy}carbonyl]amino)3-{4-(difluoro[hydroxy{(2-nitro-benzyl)oxy}phosphoryl] methyl)-phenyl}propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / 2 h / 20 °C / Inert atmosphere

2.1: sodium carbonate / acetonitrile / 20 °C / Inert atmosphere

3.1: trimethylsilyl bromide / dichloromethane / 14 h / 20 °C / Inert atmosphere

4.1: pyridine; p-toluenesulfonyl chloride / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

4.2: 26 h / 20 °C / Inert atmosphere

5.1: N-methylaniline; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

5.2: Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trimethylsilyl bromide; sodium carbonate; p-toluenesulfonyl chloride; N-methylaniline; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2014.04.002

Reference yield:

: C₁₇H₂₄F₂NO₅P

: 1609462-55-6
(2S)-2-([{(9H-fluoren-9-yl) methoxy}carbonyl]amino)3-{4-(difluoro[hydroxy{(2-nitro-benzyl)oxy}phosphoryl] methyl)-phenyl}propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / acetonitrile / 20 °C / Inert atmosphere

2.1: trimethylsilyl bromide / dichloromethane / 14 h / 20 °C / Inert atmosphere

3.1: pyridine; p-toluenesulfonyl chloride / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

3.2: 26 h / 20 °C / Inert atmosphere

4.1: N-methylaniline; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

4.2: Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trimethylsilyl bromide; sodium carbonate; p-toluenesulfonyl chloride; N-methylaniline; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2014.04.002