(S)-([4-{2-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-3-(allyloxy)-3-oxopropyl}phenyl]difluoromethyl)phosphonic acid

Base Information

Chemical Name:(S)-([4-{2-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-3-(allyloxy)-3-oxopropyl}phenyl]difluoromethyl)phosphonic acid
CAS No.:1609462-49-8
Molecular Formula:C₂₈H₂₆F₂NO₇P
Molecular Weight:557.488
Hs Code.:

Synonyms:(S)-([4-{2-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-3-(allyloxy)-3-oxopropyl}phenyl]difluoromethyl)phosphonic acid

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Chemical Property of (S)-([4-{2-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-3-(allyloxy)-3-oxopropyl}phenyl]difluoromethyl)phosphonic acid

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Technology Process of (S)-([4-{2-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-3-(allyloxy)-3-oxopropyl}phenyl]difluoromethyl)phosphonic acid

There total 4 articles about (S)-([4-{2-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-3-(allyloxy)-3-oxopropyl}phenyl]difluoromethyl)phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1609462-46-5
(S)-allyl 2-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-3-[4-{(diethoxyphosphoryl)difluoromethyl}phenyl]propanoate

: 1609462-49-8
(S)-([4-{2-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-3-(allyloxy)-3-oxopropyl}phenyl]difluoromethyl)phosphonic acid

Guidance literature:: With trimethylsilyl bromide; In dichloromethane; at 20 ℃; for 14h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.04.002

Reference yield:

: C₁₇H₂₄F₂NO₅P

: 1609462-49-8
(S)-([4-{2-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-3-(allyloxy)-3-oxopropyl}phenyl]difluoromethyl)phosphonic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / acetonitrile / 20 °C / Inert atmosphere

2: trimethylsilyl bromide / dichloromethane / 14 h / 20 °C / Inert atmosphere

With trimethylsilyl bromide; sodium carbonate; In dichloromethane; acetonitrile;
DOI:10.1016/j.bmc.2014.04.002

Reference yield:

: 150618-05-6
(2S)-2-[(tert-butoxycarbonyl)amino]-3-{4-[(diethoxyphosphoryl)(difluoro)methyl]phenyl}propanoic acid

: 1609462-49-8
(S)-([4-{2-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-3-(allyloxy)-3-oxopropyl}phenyl]difluoromethyl)phosphonic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: trifluoroacetic acid / 2 h / 20 °C / Inert atmosphere

3: sodium carbonate / acetonitrile / 20 °C / Inert atmosphere

4: trimethylsilyl bromide / dichloromethane / 14 h / 20 °C / Inert atmosphere

With trimethylsilyl bromide; sodium carbonate; potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2014.04.002