(S)-allyl 2-{(tert-butoxycarbonyl)amino}-3-[4-{(diethoxyphosphoryl)difluoromethyl}phenyl]propanoate

Base Information

Chemical Name:(S)-allyl 2-{(tert-butoxycarbonyl)amino}-3-[4-{(diethoxyphosphoryl)difluoromethyl}phenyl]propanoate
CAS No.:1609462-44-3
Molecular Formula:C₂₂H₃₂F₂NO₇P
Molecular Weight:491.469
Hs Code.:

Synonyms:(S)-allyl 2-{(tert-butoxycarbonyl)amino}-3-[4-{(diethoxyphosphoryl)difluoromethyl}phenyl]propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-allyl 2-{(tert-butoxycarbonyl)amino}-3-[4-{(diethoxyphosphoryl)difluoromethyl}phenyl]propanoate

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Technology Process of (S)-allyl 2-{(tert-butoxycarbonyl)amino}-3-[4-{(diethoxyphosphoryl)difluoromethyl}phenyl]propanoate

There total 1 articles about (S)-allyl 2-{(tert-butoxycarbonyl)amino}-3-[4-{(diethoxyphosphoryl)difluoromethyl}phenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 106-95-6
allyl bromide

: 150618-05-6
(2S)-2-[(tert-butoxycarbonyl)amino]-3-{4-[(diethoxyphosphoryl)(difluoro)methyl]phenyl}propanoic acid

: 1609462-44-3
(S)-allyl 2-{(tert-butoxycarbonyl)amino}-3-[4-{(diethoxyphosphoryl)difluoromethyl}phenyl]propanoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2014.04.002

Reference yield:

: 1609462-44-3
(S)-allyl 2-{(tert-butoxycarbonyl)amino}-3-[4-{(diethoxyphosphoryl)difluoromethyl}phenyl]propanoate

: C₁₇H₂₄F₂NO₅P

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.04.002

Reference yield:

: 1609462-44-3
(S)-allyl 2-{(tert-butoxycarbonyl)amino}-3-[4-{(diethoxyphosphoryl)difluoromethyl}phenyl]propanoate

: 1609462-55-6
(2S)-2-([{(9H-fluoren-9-yl) methoxy}carbonyl]amino)3-{4-(difluoro[hydroxy{(2-nitro-benzyl)oxy}phosphoryl] methyl)-phenyl}propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / 2 h / 20 °C / Inert atmosphere

2.1: sodium carbonate / acetonitrile / 20 °C / Inert atmosphere

3.1: trimethylsilyl bromide / dichloromethane / 14 h / 20 °C / Inert atmosphere

4.1: pyridine; p-toluenesulfonyl chloride / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

4.2: 26 h / 20 °C / Inert atmosphere

5.1: N-methylaniline; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

5.2: Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trimethylsilyl bromide; sodium carbonate; p-toluenesulfonyl chloride; N-methylaniline; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2014.04.002