(2S)-allyl 2-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-3-{4-(difluoro[hydroxy{(2-nitrobenzyl)oxy}phosphoryl]methyl)phenyl}propanoate

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Chemical Name:(2S)-allyl 2-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-3-{4-(difluoro[hydroxy{(2-nitrobenzyl)oxy}phosphoryl]methyl)phenyl}propanoate
CAS No.:1609462-52-3
Molecular Formula:C₃₅H₃₁F₂N₂O₉P
Molecular Weight:692.61
Hs Code.:

Synonyms:(2S)-allyl 2-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-3-{4-(difluoro[hydroxy{(2-nitrobenzyl)oxy}phosphoryl]methyl)phenyl}propanoate

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Chemical Property of (2S)-allyl 2-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-3-{4-(difluoro[hydroxy{(2-nitrobenzyl)oxy}phosphoryl]methyl)phenyl}propanoate

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Technology Process of (2S)-allyl 2-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-3-{4-(difluoro[hydroxy{(2-nitrobenzyl)oxy}phosphoryl]methyl)phenyl}propanoate

There total 5 articles about (2S)-allyl 2-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-3-{4-(difluoro[hydroxy{(2-nitrobenzyl)oxy}phosphoryl]methyl)phenyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 612-25-9
2-Nitrobenzyl alcohol

: 1609462-49-8
(S)-([4-{2-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-3-(allyloxy)-3-oxopropyl}phenyl]difluoromethyl)phosphonic acid

: 1609462-52-3
(2S)-allyl 2-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-3-{4-(difluoro[hydroxy{(2-nitrobenzyl)oxy}phosphoryl]methyl)phenyl}propanoate

Guidance literature:: (S)-([4-{2-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-3-(allyloxy)-3-oxopropyl}phenyl]difluoromethyl)phosphonic acid; With pyridine; p-toluenesulfonyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h; Inert atmosphere;

2-Nitrobenzyl alcohol; In N,N-dimethyl-formamide; at 20 ℃; for 26h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.04.002

Reference yield:

: C₁₇H₂₄F₂NO₅P

: 1609462-52-3
(2S)-allyl 2-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-3-{4-(difluoro[hydroxy{(2-nitrobenzyl)oxy}phosphoryl]methyl)phenyl}propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / acetonitrile / 20 °C / Inert atmosphere

2.1: trimethylsilyl bromide / dichloromethane / 14 h / 20 °C / Inert atmosphere

3.1: pyridine; p-toluenesulfonyl chloride / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

3.2: 26 h / 20 °C / Inert atmosphere

With pyridine; trimethylsilyl bromide; sodium carbonate; p-toluenesulfonyl chloride; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2014.04.002

Reference yield:

: 150618-05-6
(2S)-2-[(tert-butoxycarbonyl)amino]-3-{4-[(diethoxyphosphoryl)(difluoro)methyl]phenyl}propanoic acid

: 1609462-52-3
(2S)-allyl 2-([{(9H-fluoren-9-yl)methoxy}carbonyl]amino)-3-{4-(difluoro[hydroxy{(2-nitrobenzyl)oxy}phosphoryl]methyl)phenyl}propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / 2 h / 20 °C / Inert atmosphere

3.1: sodium carbonate / acetonitrile / 20 °C / Inert atmosphere

4.1: trimethylsilyl bromide / dichloromethane / 14 h / 20 °C / Inert atmosphere

5.1: pyridine; p-toluenesulfonyl chloride / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

5.2: 26 h / 20 °C / Inert atmosphere

With pyridine; trimethylsilyl bromide; sodium carbonate; potassium carbonate; p-toluenesulfonyl chloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2014.04.002