Malonic acid 1-benzyloxy-5-phenylsulfanyl-pent-3-ynyl ester ethyl ester

Base Information

• Chemical Name: Malonic acid 1-benzyloxy-5-phenylsulfanyl-pent-3-ynyl ester ethyl ester
• CAS No.: 128669-71-6
• Molecular Formula: C₂₃H₂₄O₅S
• Molecular Weight: 412.507
• Mol file: 128669-71-6.mol

Synonyms:Malonic acid 1-benzyloxy-5-phenylsulfanyl-pent-3-ynyl ester ethyl ester

Chemical Property of Malonic acid 1-benzyloxy-5-phenylsulfanyl-pent-3-ynyl ester ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Malonic acid 1-benzyloxy-5-phenylsulfanyl-pent-3-ynyl ester ethyl ester

There total 3 articles about Malonic acid 1-benzyloxy-5-phenylsulfanyl-pent-3-ynyl ester ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

hydrogen ethyl malonate (1071-46-1) + 1-Benzyloxy-5-phenylsulfanyl-pent-3-yn-1-ol (128669-68-1) → Malonic acid 1-benzyloxy-5-phenylsulfanyl-pent-3-ynyl ester ethyl ester (128669-71-6)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; Ambient temperature;

DOI:10.1039/c39900000418

Reference yield:

benzylglycidyl ether (70278-02-3) → Malonic acid 1-benzyloxy-5-phenylsulfanyl-pent-3-ynyl ester ethyl ester (128669-71-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) BF₃*Et₂O / 1.) THF, -78 deg C

2: 90 percent / dicyclohexylcarbodiimide, 4-N,N-dimethylaminopyridine / CH₂Cl₂ / Ambient temperature

With dmap; boron trifluoride diethyl etherate; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1039/c39900000418

Reference yield:

C9H7LiS → Malonic acid 1-benzyloxy-5-phenylsulfanyl-pent-3-ynyl ester ethyl ester (128669-71-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) BF₃*Et₂O / 1.) THF, -78 deg C

2: 90 percent / dicyclohexylcarbodiimide, 4-N,N-dimethylaminopyridine / CH₂Cl₂ / Ambient temperature

With dmap; boron trifluoride diethyl etherate; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1039/c39900000418

upstream raw materials:

hydrogen ethyl malonate

1-Benzyloxy-5-phenylsulfanyl-pent-3-yn-1-ol

benzylglycidyl ether

Downstream raw materials:

(3S,4S,6S)-6-Benzyloxy-2-oxo-3-phenylsulfanyl-4-vinyl-tetrahydro-pyran-3-carboxylic acid ethyl ester

(3S,4S,6R)-6-Benzyloxy-2-oxo-3-phenylsulfanyl-4-vinyl-tetrahydro-pyran-3-carboxylic acid ethyl ester

2-Diazo-malonic acid (Z)-1-benzyloxy-5-phenylsulfanyl-pent-3-enyl ester ethyl ester

Malonic acid (Z)-1-benzyloxy-5-phenylsulfanyl-pent-3-enyl ester ethyl ester