1-Benzyloxy-5-phenylsulfanyl-pent-3-yn-1-ol

Base Information

• Chemical Name: 1-Benzyloxy-5-phenylsulfanyl-pent-3-yn-1-ol
• CAS No.: 128669-68-1
• Molecular Formula: C₁₈H₁₈O₂S
• Molecular Weight: 298.406
• Mol file: 128669-68-1.mol

Synonyms:1-Benzyloxy-5-phenylsulfanyl-pent-3-yn-1-ol

Chemical Property of 1-Benzyloxy-5-phenylsulfanyl-pent-3-yn-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Benzyloxy-5-phenylsulfanyl-pent-3-yn-1-ol

There total 1 articles about 1-Benzyloxy-5-phenylsulfanyl-pent-3-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzylglycidyl ether (70278-02-3) + C9H7LiS → 1-Benzyloxy-5-phenylsulfanyl-pent-3-yn-1-ol (128669-68-1)

Guidance literature:

With boron trifluoride diethyl etherate; Yield given. Multistep reaction; 1.) THF, -78 deg C;

DOI:10.1039/c39900000418

Reference yield: 90.0%

hydrogen ethyl malonate (1071-46-1) + 1-Benzyloxy-5-phenylsulfanyl-pent-3-yn-1-ol (128669-68-1) → Malonic acid 1-benzyloxy-5-phenylsulfanyl-pent-3-ynyl ester ethyl ester (128669-71-6)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; Ambient temperature;

DOI:10.1039/c39900000418

Reference yield:

1-Benzyloxy-5-phenylsulfanyl-pent-3-yn-1-ol (128669-68-1) → Malonic acid (Z)-1-benzyloxy-5-phenylsulfanyl-pent-3-enyl ester ethyl ester (128669-74-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / dicyclohexylcarbodiimide, 4-N,N-dimethylaminopyridine / CH₂Cl₂ / Ambient temperature

2: 81 percent / H₂ / 5percent Pd-BaSO₄ / methanol

With dmap; hydrogen; dicyclohexyl-carbodiimide; palladium on barium sulfate; In methanol; dichloromethane;

DOI:10.1039/c39900000418

upstream raw materials:

benzylglycidyl ether

Downstream raw materials:

Malonic acid 1-benzyloxy-5-phenylsulfanyl-pent-3-ynyl ester ethyl ester

Malonic acid (Z)-1-benzyloxy-5-phenylsulfanyl-pent-3-enyl ester ethyl ester

2-Diazo-malonic acid (Z)-1-benzyloxy-5-phenylsulfanyl-pent-3-enyl ester ethyl ester

(3S,4S,6R)-6-Benzyloxy-2-oxo-3-phenylsulfanyl-4-vinyl-tetrahydro-pyran-3-carboxylic acid ethyl ester