N-<2-methoxy-2-(3,4-dimethoxyphenyl)ethyl>-4-nitrobenzeneacetamide

Base Information

• Chemical Name: N-<2-methoxy-2-(3,4-dimethoxyphenyl)ethyl>-4-nitrobenzeneacetamide
• CAS No.: 26193-61-3
• Molecular Formula: C₁₉H₂₂N₂O₆
• Molecular Weight: 374.393
• Mol file: 26193-61-3.mol

Synonyms:N-<2-methoxy-2-(3,4-dimethoxyphenyl)ethyl>-4-nitrobenzeneacetamide

Chemical Property of N-<2-methoxy-2-(3,4-dimethoxyphenyl)ethyl>-4-nitrobenzeneacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<2-methoxy-2-(3,4-dimethoxyphenyl)ethyl>-4-nitrobenzeneacetamide

There total 5 articles about N-<2-methoxy-2-(3,4-dimethoxyphenyl)ethyl>-4-nitrobenzeneacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

3,4-dimethoxy-β-methoxybenzeneethanamine (4722-08-1,783256-00-8) + 4-nitrophenylacetyl chloride (50434-36-1) → N-<2-methoxy-2-(3,4-dimethoxyphenyl)ethyl>-4-nitrobenzeneacetamide (26193-61-3)

Guidance literature:

With potassium carbonate; In chloroform; for 3h; Ambient temperature;

DOI:10.1021/jm00356a011

Reference yield:

1,2-dimethoxy-4-(2-nitro-vinyl)-benzene (4230-93-7) → N-<2-methoxy-2-(3,4-dimethoxyphenyl)ethyl>-4-nitrobenzeneacetamide (26193-61-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 44 percent / methanol

2: 78 percent / H₂ / Raney Ni / ethanol / 2844.3 Torr

3: 53 percent / 20percent K₂CO₃ / CHCl₃ / 3 h / Ambient temperature

With hydrogen; potassium carbonate; nickel; In methanol; ethanol; chloroform;

DOI:10.1021/jm00356a011

Reference yield:

(dimethoxy-3,4 phenyl)-2 methoxy-2 nitro-1 ethane (57542-90-2) → N-<2-methoxy-2-(3,4-dimethoxyphenyl)ethyl>-4-nitrobenzeneacetamide (26193-61-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / H₂ / Raney Ni / ethanol / 2844.3 Torr

2: 53 percent / 20percent K₂CO₃ / CHCl₃ / 3 h / Ambient temperature

With hydrogen; potassium carbonate; nickel; In ethanol; chloroform;

DOI:10.1021/jm00356a011

upstream raw materials:

3,4-dimethoxy-β-methoxybenzeneethanamine

4-nitrophenylacetyl chloride

(dimethoxy-3,4 phenyl)-2 methoxy-2 nitro-1 ethane

1,2-dimethoxy-4-(2-nitro-vinyl)-benzene

Downstream raw materials:

methyl (E)-4-({4-[(6,7-dimethoxy-1-isoquinolinyl)methyl]phenyl}amino)-4-oxo-2-butenoate

methyl (Z)-4-({4-[(6,7-dimethoxy-1-isoquinolinyl)methyl]phenyl}amino)-4-oxo-2-butenoate

2-chloro-N-{4-[(6,7-dimethoxy-1-isoquinolinyl)methyl]phenyl}acetamide

N,N-bis(2-chloroethyl)-4-[(6,7-dimethoxy-1-isoquinolinyl)methyl]benzenamine