methyl (E)-4-({4-[(6,7-dimethoxy-1-isoquinolinyl)methyl]phenyl}amino)-4-oxo-2-butenoate

Base Information

Chemical Name:methyl (E)-4-({4-[(6,7-dimethoxy-1-isoquinolinyl)methyl]phenyl}amino)-4-oxo-2-butenoate
CAS No.:83633-30-1
Molecular Formula:C₂₃H₂₂N₂O₅
Molecular Weight:406.438
Hs Code.:

Synonyms:methyl (E)-4-({4-[(6,7-dimethoxy-1-isoquinolinyl)methyl]phenyl}amino)-4-oxo-2-butenoate

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Chemical Property of methyl (E)-4-({4-[(6,7-dimethoxy-1-isoquinolinyl)methyl]phenyl}amino)-4-oxo-2-butenoate

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Technology Process of methyl (E)-4-({4-[(6,7-dimethoxy-1-isoquinolinyl)methyl]phenyl}amino)-4-oxo-2-butenoate

There total 13 articles about methyl (E)-4-({4-[(6,7-dimethoxy-1-isoquinolinyl)methyl]phenyl}amino)-4-oxo-2-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 83633-30-1
methyl (E)-4-({4-[(6,7-dimethoxy-1-isoquinolinyl)methyl]phenyl}amino)-4-oxo-2-butenoate

Guidance literature:: Multi-step reaction with 6 steps

1: ZnI₂ / 2 h / 30 °C

2: 36 percent / LiAlH₄ / tetrahydrofuran / 15 h / Heating

3: 65 percent / 20percent K₂CO₃ / CHCl₃ / 3 h / Ambient temperature

4: 63 percent / phosphorus oxychloride / acetonitrile / 0.5 h / Heating

5: 54 percent / H₂ / Raney Ni / ethanol

6: CHCl₃ / 1 h / Heating

With lithium aluminium tetrahydride; hydrogen; potassium carbonate; zinc(II) iodide; trichlorophosphate; nickel; In tetrahydrofuran; ethanol; chloroform; acetonitrile;
DOI:10.1021/jm00356a011

Reference yield:

: 6924-15-8
2-amino-1-(3,4-dimethoxy-phenyl)-ethanol

: 83633-30-1
methyl (E)-4-({4-[(6,7-dimethoxy-1-isoquinolinyl)methyl]phenyl}amino)-4-oxo-2-butenoate

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / 20percent K₂CO₃ / CHCl₃ / 3 h / Ambient temperature

2: 63 percent / phosphorus oxychloride / acetonitrile / 0.5 h / Heating

3: 54 percent / H₂ / Raney Ni / ethanol

4: CHCl₃ / 1 h / Heating

With hydrogen; potassium carbonate; trichlorophosphate; nickel; In ethanol; chloroform; acetonitrile;
DOI:10.1021/jm00356a011

Reference yield:

: 6309-18-8
2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile

: 83633-30-1
methyl (E)-4-({4-[(6,7-dimethoxy-1-isoquinolinyl)methyl]phenyl}amino)-4-oxo-2-butenoate

Guidance literature:: Multi-step reaction with 5 steps

1: 35 percent / LiAlH₄ / tetrahydrofuran / 36 h / Heating

2: 65 percent / 20percent K₂CO₃ / CHCl₃ / 3 h / Ambient temperature

3: 63 percent / phosphorus oxychloride / acetonitrile / 0.5 h / Heating

4: 54 percent / H₂ / Raney Ni / ethanol

5: CHCl₃ / 1 h / Heating

With lithium aluminium tetrahydride; hydrogen; potassium carbonate; trichlorophosphate; nickel; In tetrahydrofuran; ethanol; chloroform; acetonitrile;
DOI:10.1021/jm00356a011