5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-3-isopropyl-1H-pyrazole

Base Information

• Chemical Name: 5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-3-isopropyl-1H-pyrazole
• CAS No.: 1033586-33-2
• Molecular Formula: C₁₉H₁₇BrCl₂N₂O
• Molecular Weight: 440.167
• Mol file: 1033586-33-2.mol

Synonyms:5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-3-isopropyl-1H-pyrazole

Chemical Property of 5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-3-isopropyl-1H-pyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-3-isopropyl-1H-pyrazole

There total 6 articles about 5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-3-isopropyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-[5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-1H-pyrazol-3-yl]-propan-2-ol (1033586-32-1) → 5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-3-isopropyl-1H-pyrazole (1033586-33-2)

Guidance literature:

2-[5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-1H-pyrazol-3-yl]-propan-2-ol; With triethylsilane; trifluoroacetic acid; for 1h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

1-(2,6-dichlorophenyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester (1033586-29-6) → 5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-3-isopropyl-1H-pyrazole (1033586-33-2)

Guidance literature:

Multi-step reaction with 4 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 2 h / Heating / reflux; high intensity lamp

2: potassium carbonate / acetonitrile / 4 h / Heating / reflux

3: tetrahydrofuran / 1.17 h / 0 - 20 °C

4: triethylsilane; trifluoroacetic acid / 1 h

With triethylsilane; N-Bromosuccinimide; potassium carbonate; trifluoroacetic acid; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; acetonitrile;

Reference yield:

5-bromomethyl-1-(2,6-dichlorophenyl)-1H-pyrazole-3-carboxylic acid ethyl ester (1033586-30-9) → 5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-3-isopropyl-1H-pyrazole (1033586-33-2)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 4 h / Heating / reflux

2: tetrahydrofuran / 1.17 h / 0 - 20 °C

3: triethylsilane; trifluoroacetic acid / 1 h

With triethylsilane; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; acetonitrile;

upstream raw materials:

2-[5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-1H-pyrazol-3-yl]-propan-2-ol

1-(2,6-dichlorophenyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

5-bromomethyl-1-(2,6-dichlorophenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

Downstream raw materials:

2-chloro-4'-[2-(2,6-dichlorophenyl)-5-isopropyl-2H-pyrazol-3-ylmethoxy]biphenyl-4-carboxylic acid