2-[5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-1H-pyrazol-3-yl]-propan-2-ol

Base Information

• Chemical Name: 2-[5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-1H-pyrazol-3-yl]-propan-2-ol
• CAS No.: 1033586-32-1
• Molecular Formula: C₁₉H₁₇BrCl₂N₂O₂
• Molecular Weight: 456.166
• Mol file: 1033586-32-1.mol

Synonyms:2-[5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-1H-pyrazol-3-yl]-propan-2-ol

Chemical Property of 2-[5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-1H-pyrazol-3-yl]-propan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-1H-pyrazol-3-yl]-propan-2-ol

There total 5 articles about 2-[5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-1H-pyrazol-3-yl]-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-1H-pyrazole-3-carboxylic acid ethyl ester (1033586-31-0) + methylmagnesium bromide (75-16-1) → 2-[5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-1H-pyrazol-3-yl]-propan-2-ol (1033586-32-1)

Guidance literature:

5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-1H-pyrazole-3-carboxylic acid ethyl ester; methylmagnesium bromide; In tetrahydrofuran; at 0 - 20 ℃; for 1.16667h;

With ammonium chloride; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

1-(2,6-dichlorophenyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester (1033586-29-6) → 2-[5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-1H-pyrazol-3-yl]-propan-2-ol (1033586-32-1)

Guidance literature:

Multi-step reaction with 3 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 2 h / Heating / reflux; high intensity lamp

2: potassium carbonate / acetonitrile / 4 h / Heating / reflux

3: tetrahydrofuran / 1.17 h / 0 - 20 °C

With N-Bromosuccinimide; potassium carbonate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; acetonitrile;

Reference yield:

5-bromomethyl-1-(2,6-dichlorophenyl)-1H-pyrazole-3-carboxylic acid ethyl ester (1033586-30-9) → 2-[5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-1H-pyrazol-3-yl]-propan-2-ol (1033586-32-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 4 h / Heating / reflux

2: tetrahydrofuran / 1.17 h / 0 - 20 °C

With potassium carbonate; In tetrahydrofuran; acetonitrile;

upstream raw materials:

5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

methylmagnesium bromide

1-(2,6-dichlorophenyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

5-bromomethyl-1-(2,6-dichlorophenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

Downstream raw materials:

2-chloro-4'-[2-(2,6-dichlorophenyl)-5-(1-hydroxy-1-methylethyl)-2H-pyrazol-3-ylmethoxy]biphenyl-4-carboxylic acid

5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-3-isopropyl-1H-pyrazole

2-chloro-4'-[2-(2,6-dichlorophenyl)-5-isopropyl-2H-pyrazol-3-ylmethoxy]biphenyl-4-carboxylic acid