2-chloro-4'-[2-(2,6-dichlorophenyl)-5-isopropyl-2H-pyrazol-3-ylmethoxy]biphenyl-4-carboxylic acid

Base Information

• Chemical Name: 2-chloro-4'-[2-(2,6-dichlorophenyl)-5-isopropyl-2H-pyrazol-3-ylmethoxy]biphenyl-4-carboxylic acid
• CAS No.: 1033575-52-8
• Molecular Formula: C₂₆H₂₁Cl₃N₂O₃
• Molecular Weight: 515.823
• Mol file: 1033575-52-8.mol

Synonyms:2-chloro-4'-[2-(2,6-dichlorophenyl)-5-isopropyl-2H-pyrazol-3-ylmethoxy]biphenyl-4-carboxylic acid

Chemical Property of 2-chloro-4'-[2-(2,6-dichlorophenyl)-5-isopropyl-2H-pyrazol-3-ylmethoxy]biphenyl-4-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-4'-[2-(2,6-dichlorophenyl)-5-isopropyl-2H-pyrazol-3-ylmethoxy]biphenyl-4-carboxylic acid

There total 7 articles about 2-chloro-4'-[2-(2,6-dichlorophenyl)-5-isopropyl-2H-pyrazol-3-ylmethoxy]biphenyl-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

2-chloro-4-carboxybenzeneboronic acid (851335-09-6) + 5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-3-isopropyl-1H-pyrazole (1033586-33-2) → 2-chloro-4'-[2-(2,6-dichlorophenyl)-5-isopropyl-2H-pyrazol-3-ylmethoxy]biphenyl-4-carboxylic acid (1033575-52-8)

Guidance literature:

With water; potassium carbonate; (1,1'-bis(diphenylphosphine)ferrocene)palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 80 ℃; for 4h;

Reference yield:

1-(2,6-dichlorophenyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester (1033586-29-6) → 2-chloro-4'-[2-(2,6-dichlorophenyl)-5-isopropyl-2H-pyrazol-3-ylmethoxy]biphenyl-4-carboxylic acid (1033575-52-8)

Guidance literature:

Multi-step reaction with 5 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 2 h / Heating / reflux; high intensity lamp

2: potassium carbonate / acetonitrile / 4 h / Heating / reflux

3: tetrahydrofuran / 1.17 h / 0 - 20 °C

4: triethylsilane; trifluoroacetic acid / 1 h

5: water; potassium carbonate / (1,1'-bis(diphenylphosphine)ferrocene)palladium⁽⁰⁾ / 1,2-dimethoxyethane / 4 h / 80 °C

With triethylsilane; N-Bromosuccinimide; water; potassium carbonate; trifluoroacetic acid; dibenzoyl peroxide; (1,1'-bis(diphenylphosphine)ferrocene)palladium⁽⁰⁾; In tetrahydrofuran; tetrachloromethane; 1,2-dimethoxyethane; acetonitrile; 5: Suzuki Coupling;

Reference yield:

5-bromomethyl-1-(2,6-dichlorophenyl)-1H-pyrazole-3-carboxylic acid ethyl ester (1033586-30-9) → 2-chloro-4'-[2-(2,6-dichlorophenyl)-5-isopropyl-2H-pyrazol-3-ylmethoxy]biphenyl-4-carboxylic acid (1033575-52-8)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 4 h / Heating / reflux

2: tetrahydrofuran / 1.17 h / 0 - 20 °C

3: triethylsilane; trifluoroacetic acid / 1 h

4: water; potassium carbonate / (1,1'-bis(diphenylphosphine)ferrocene)palladium⁽⁰⁾ / 1,2-dimethoxyethane / 4 h / 80 °C

With triethylsilane; water; potassium carbonate; trifluoroacetic acid; (1,1'-bis(diphenylphosphine)ferrocene)palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; acetonitrile; 4: Suzuki Coupling;

upstream raw materials:

2-chloro-4-carboxybenzeneboronic acid

5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-3-isopropyl-1H-pyrazole

1-(2,6-dichlorophenyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

5-bromomethyl-1-(2,6-dichlorophenyl)-1H-pyrazole-3-carboxylic acid ethyl ester