1-(2,6-dichlorophenyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 1-(2,6-dichlorophenyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester
• CAS No.: 1033586-29-6
• Molecular Formula: C₁₃H₁₂Cl₂N₂O₂
• Molecular Weight: 299.156
• Mol file: 1033586-29-6.mol

Synonyms:1-(2,6-dichlorophenyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

Chemical Property of 1-(2,6-dichlorophenyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

1-(2,6-Dichloro-phenyl)-5-methyl-1H-pyrazole-3-carboxylicacidethylester 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,6-dichlorophenyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester

There total 1 articles about 1-(2,6-dichlorophenyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

ethyl 2,4-diketopentanoate (615-79-2) + (2,6-dichlorophenyl)hydrazine (14763-24-7) → 1-(2,6-dichlorophenyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester (1033586-29-6)

Guidance literature:

ethyl 2,4-diketopentanoate; (2,6-dichlorophenyl)hydrazine; In ethanol; acetic acid; at 80 ℃; for 18h;

With sodium hydroxide; In ethanol; water; ethyl acetate;

Reference yield: 38.0%

1-(2,6-dichlorophenyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester (1033586-29-6) → 5-bromomethyl-1-(2,6-dichlorophenyl)-1H-pyrazole-3-carboxylic acid ethyl ester (1033586-30-9)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 2h; Heating / reflux; high intensity lamp;

Reference yield:

1-(2,6-dichlorophenyl)-5-methyl-1H-pyrazole-3-carboxylic acid ethyl ester (1033586-29-6) → 2-chloro-4'-[2-(2,6-dichlorophenyl)-5-isopropyl-2H-pyrazol-3-ylmethoxy]biphenyl-4-carboxylic acid (1033575-52-8)

Guidance literature:

Multi-step reaction with 5 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 2 h / Heating / reflux; high intensity lamp

2: potassium carbonate / acetonitrile / 4 h / Heating / reflux

3: tetrahydrofuran / 1.17 h / 0 - 20 °C

4: triethylsilane; trifluoroacetic acid / 1 h

5: water; potassium carbonate / (1,1'-bis(diphenylphosphine)ferrocene)palladium⁽⁰⁾ / 1,2-dimethoxyethane / 4 h / 80 °C

With triethylsilane; N-Bromosuccinimide; water; potassium carbonate; trifluoroacetic acid; dibenzoyl peroxide; (1,1'-bis(diphenylphosphine)ferrocene)palladium⁽⁰⁾; In tetrahydrofuran; tetrachloromethane; 1,2-dimethoxyethane; acetonitrile; 5: Suzuki Coupling;

upstream raw materials:

ethyl 2,4-diketopentanoate

(2,6-dichlorophenyl)hydrazine

Downstream raw materials:

5-bromomethyl-1-(2,6-dichlorophenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-3-isopropyl-1H-pyrazole

2-[5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-1H-pyrazol-3-yl]-propan-2-ol

5-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-1H-pyrazole-3-carboxylic acid ethyl ester