N-(phenyl)-N-methyl-2-chlorocinnamamide

Base Information

Chemical Name:N-(phenyl)-N-methyl-2-chlorocinnamamide
CAS No.:349423-35-4
Molecular Formula:C₁₆H₁₄ClNO
Molecular Weight:271.746
Hs Code.:

Synonyms:N-(phenyl)-N-methyl-2-chlorocinnamamide

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Chemical Property of N-(phenyl)-N-methyl-2-chlorocinnamamide

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Technology Process of N-(phenyl)-N-methyl-2-chlorocinnamamide

There total 4 articles about N-(phenyl)-N-methyl-2-chlorocinnamamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 124-38-9,18923-20-1
carbon dioxide

: 6273-94-5
N-methyl-N-phenylacrylamide

: 3900-89-8
2-Chlorobenzeneboronic acid

: 74-88-4
methyl iodide

: 349423-35-4
N-(phenyl)-N-methyl-2-chlorocinnamamide

: C₁₆H₁₆ClNO

: methyl 2-(2-chlorobenzyl)-3-(methyl(phenyl)amino)-3-oxopropanoate

Guidance literature:: carbon dioxide; N-methyl-N-phenylacrylamide; 2-Chlorobenzeneboronic acid; With chloro(1,5-cyclooctadiene)rhodium(I) dimer; N,N,N',N'',N'''-pentamethyldiethylenetriamine; potassium tert-butylate; silver(l) oxide; In N,N-dimethyl acetamide; at 60 ℃; for 24h; Sealed tube; Green chemistry;

methyl iodide; With potassium carbonate; In N,N-dimethyl acetamide; at 60 ℃; for 2h; regioselective reaction; Green chemistry;
DOI:10.1039/d0gc02667k

Reference yield:

: 100-61-8
N-methylaniline

: 120681-06-3,35086-82-9
3-(2-chlorophenyl)propenoyl chloride

: 349423-35-4
N-(phenyl)-N-methyl-2-chlorocinnamamide

Guidance literature:: In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/ol403196h

Reference yield:

: 3752-25-8,939-58-2
o-chlorocinnamic acid

: 349423-35-4
N-(phenyl)-N-methyl-2-chlorocinnamamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 3 h / 60 °C

2: dichloromethane / 1 h / 20 °C

With thionyl chloride; In dichloromethane;
DOI:10.1021/ol403196h