(2-phenylethyl)amine

Base Information

• Chemical Name: (2-phenylethyl)amine
• CAS No.: 114779-47-4
• Molecular Formula: C₂₀H₂₃N₃O
• Molecular Weight: 321.422
• Mol file: 114779-47-4.mol

Synonyms:(2-phenylethyl)amine

Chemical Property of (2-phenylethyl)amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-phenylethyl)amine

There total 6 articles about (2-phenylethyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

[1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl]carbamic acid,9H-fluoren-9-ylmethyl ester (114779-46-3) → (2-phenylethyl)amine (114779-47-4)

Guidance literature:

With piperidine; In N,N-dimethyl-formamide;

DOI:10.1021/jm00072a005

Reference yield: 83.0%

piperidine (110-89-4) + [1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl]carbamic acid,9H-fluoren-9-ylmethyl ester (114779-46-3) → (2-phenylethyl)amine (114779-47-4)

Guidance literature:

With sodium hydroxide; In N-methyl-acetamide; hydrogenchloride;

Reference yield:

N-(Fmoc)-DL-α-methyltryptophal (114779-80-5) → (2-phenylethyl)amine (114779-47-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) BOP, DIEA / 1.) DMF, RT, 45 min, 2.) DMF, RT, 7 d

2: 88 percent / piperidine / dimethylformamide

With piperidine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm00072a005

upstream raw materials:

[1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl]carbamic acid,9H-fluoren-9-ylmethyl ester

DL-α-methyltryptophan

N-(Fmoc)-DL-α-methyltryptophal

phenethylamine

Downstream raw materials:

N-tert-butylacetyl-DL-α-methyl tryptophanyl-2-phenylethylamide

tricyclo<3.3.1.1^3,7>dec-1-yl (+/-)-<1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-<(2-phenylethyl)amino>ethyl>carbamate

tricyclo[3.3.1.13,7 ]dec-2-yl [1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]-ethyl]carbamate