dimethyl 2,6-dimethyl-4-<2-(1,3-dioxolan-2-yl)-4-methoxyphenyl>-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

Chemical Name:dimethyl 2,6-dimethyl-4-<2-(1,3-dioxolan-2-yl)-4-methoxyphenyl>-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:98015-09-9
Molecular Formula:C₂₁H₂₅NO₇
Molecular Weight:403.432
Hs Code.:

Synonyms:dimethyl 2,6-dimethyl-4-<2-(1,3-dioxolan-2-yl)-4-methoxyphenyl>-1,4-dihydropyridine-3,5-dicarboxylate

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Chemical Property of dimethyl 2,6-dimethyl-4-<2-(1,3-dioxolan-2-yl)-4-methoxyphenyl>-1,4-dihydropyridine-3,5-dicarboxylate

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Technology Process of dimethyl 2,6-dimethyl-4-<2-(1,3-dioxolan-2-yl)-4-methoxyphenyl>-1,4-dihydropyridine-3,5-dicarboxylate

There total 3 articles about dimethyl 2,6-dimethyl-4-<2-(1,3-dioxolan-2-yl)-4-methoxyphenyl>-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 105-45-3
acetoacetic acid methyl ester

: 98015-08-8
2-<2-(1,3-dioxalanyl)>-4-methoxybenzaldehyde

: 14205-39-1
methyl 3-aminocrotonate

: 98015-09-9
dimethyl 2,6-dimethyl-4-<2-(1,3-dioxolan-2-yl)-4-methoxyphenyl>-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: In isopropyl alcohol; for 20h; Heating;
DOI:10.1021/jo00221a030

Reference yield:

: 7507-86-0
2-bromo-5-methoxy-benzaldehyde

: 98015-09-9
dimethyl 2,6-dimethyl-4-<2-(1,3-dioxolan-2-yl)-4-methoxyphenyl>-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / p-toluenesulfonic acid monohydrate / toluene / 12 h / Heating

2: 1.) n-BuLi / 1.) THF, -78 deg C, 0.5 h, 2.) THF, from -78 deg C to RT, 4 h

3: 27 percent / propan-2-ol / 20 h / Heating

With n-butyllithium; toluene-4-sulfonic acid; In isopropyl alcohol; toluene;
DOI:10.1021/jo00221a030

Reference yield:

: 98015-07-7
2-Bromo-5-methoxybenzaldehyde ethylene glycol acetal

: 98015-09-9
dimethyl 2,6-dimethyl-4-<2-(1,3-dioxolan-2-yl)-4-methoxyphenyl>-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, -78 deg C, 0.5 h, 2.) THF, from -78 deg C to RT, 4 h

2: 27 percent / propan-2-ol / 20 h / Heating

With n-butyllithium; In isopropyl alcohol;
DOI:10.1021/jo00221a030