(2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2-methyl-pyridin-4-yl)-2-trifluoromethylphenylsulfanyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)-amide

Base Information

Chemical Name:(2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2-methyl-pyridin-4-yl)-2-trifluoromethylphenylsulfanyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)-amide
CAS No.:1434818-81-1
Molecular Formula:C₂₇H₂₇F₃N₄O₂S
Molecular Weight:528.598
Hs Code.:

(2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2-methyl-pyridin-4-yl)-2-trifluoromethylphenylsulfanyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)-amide

Synonyms:(2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2-methyl-pyridin-4-yl)-2-trifluoromethylphenylsulfanyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2-methyl-pyridin-4-yl)-2-trifluoromethylphenylsulfanyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)-amide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2-methyl-pyridin-4-yl)-2-trifluoromethylphenylsulfanyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)-amide

There total 11 articles about (2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2-methyl-pyridin-4-yl)-2-trifluoromethylphenylsulfanyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1434817-41-0
3-[4-(2-methylpyridin-4-yl)-2-trifluoromethylphenylsulfanyl]propionamide

: 1434818-32-2
benzenesulfonic acid (3S,5S)-5-(1-cyanocyclopropylcarbamoyl)-1-(1-methylcyclopropanecarbonyl)pyrrolidin-3-yl ester

: 1434818-81-1
(2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2-methyl-pyridin-4-yl)-2-trifluoromethylphenylsulfanyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)-amide

Guidance literature:: 3-[4-(2-methylpyridin-4-yl)-2-trifluoromethylphenylsulfanyl]propionamide; With sodium t-butanolate; In tetrahydrofuran; N,N-dimethyl acetamide; at 20 ℃; for 4h;

benzenesulfonic acid (3S,5S)-5-(1-cyanocyclopropylcarbamoyl)-1-(1-methylcyclopropanecarbonyl)pyrrolidin-3-yl ester; In tetrahydrofuran; N,N-dimethyl acetamide; at 20 ℃; for 65h;

Reference yield:

: 1208075-10-8
4-bromo-2-(trifluoromethyl)benzenethiol

: 1434818-81-1
(2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2-methyl-pyridin-4-yl)-2-trifluoromethylphenylsulfanyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: borax / water; methanol / 40 h / 20 °C

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / N,N-dimethyl-formamide / 22 h / 80 °C

2.2: 20.5 h / 20 - 60 °C

3.1: sodium t-butanolate / tetrahydrofuran; N,N-dimethyl acetamide / 4 h / 20 °C

3.2: 65 h / 20 °C

With borax; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; sodium t-butanolate; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;

Reference yield:

: 1434817-47-6
3-(4-bromo-2-trifluoromethyl-phenylsulfanyl)propionamide

: 1434818-81-1
(2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2-methyl-pyridin-4-yl)-2-trifluoromethylphenylsulfanyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / N,N-dimethyl-formamide / 22 h / 80 °C

1.2: 20.5 h / 20 - 60 °C

2.1: sodium t-butanolate / tetrahydrofuran; N,N-dimethyl acetamide / 4 h / 20 °C

2.2: 65 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; sodium t-butanolate; In tetrahydrofuran; N,N-dimethyl acetamide; N,N-dimethyl-formamide;