benzenesulfonic acid (3S,5S)-5-(1-cyanocyclopropylcarbamoyl)-1-(1-methylcyclopropanecarbonyl)pyrrolidin-3-yl ester

Base Information

Chemical Name:benzenesulfonic acid (3S,5S)-5-(1-cyanocyclopropylcarbamoyl)-1-(1-methylcyclopropanecarbonyl)pyrrolidin-3-yl ester
CAS No.:1434818-32-2
Molecular Formula:C₂₀H₂₃N₃O₅S
Molecular Weight:417.486
Hs Code.:

Synonyms:benzenesulfonic acid (3S,5S)-5-(1-cyanocyclopropylcarbamoyl)-1-(1-methylcyclopropanecarbonyl)pyrrolidin-3-yl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzenesulfonic acid (3S,5S)-5-(1-cyanocyclopropylcarbamoyl)-1-(1-methylcyclopropanecarbonyl)pyrrolidin-3-yl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of benzenesulfonic acid (3S,5S)-5-(1-cyanocyclopropylcarbamoyl)-1-(1-methylcyclopropanecarbonyl)pyrrolidin-3-yl ester

There total 7 articles about benzenesulfonic acid (3S,5S)-5-(1-cyanocyclopropylcarbamoyl)-1-(1-methylcyclopropanecarbonyl)pyrrolidin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1434816-66-6
(2S,4S)-4-hydroxy-1-(1-methyl-cyclopropanecarbonyl)-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide

: 98-09-9
benzenesulfonyl chloride

: 1434818-32-2
benzenesulfonic acid (3S,5S)-5-(1-cyanocyclopropylcarbamoyl)-1-(1-methylcyclopropanecarbonyl)pyrrolidin-3-yl ester

Guidance literature:: (2S,4S)-4-hydroxy-1-(1-methyl-cyclopropanecarbonyl)-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide; benzenesulfonyl chloride; With dmap; triethylamine; In dichloromethane; at 20 ℃; for 16h;

With hydrogenchloride; In dichloromethane; water;

Reference yield:

: 6914-76-7
1-Methyl-cyclopropanoic acid

: 1434818-32-2
benzenesulfonic acid (3S,5S)-5-(1-cyanocyclopropylcarbamoyl)-1-(1-methylcyclopropanecarbonyl)pyrrolidin-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide; thionyl chloride / 2 h / -40 - 40 °C

2.1: triethylamine; dmap / dichloromethane / 2.5 h / 0 °C

2.2: 1.5 h / 0 °C

3.1: sodium hydroxide / 1 h / 0 - 20 °C

3.2: 21 h / 70 °C

4.1: triethylamine; dmap / dichloromethane / 16 h / 20 °C

With dmap; thionyl chloride; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In dichloromethane;

Reference yield:

: 16480-05-0
1-methylcyclopropanecarbonyl chloride

: 1434818-32-2
benzenesulfonic acid (3S,5S)-5-(1-cyanocyclopropylcarbamoyl)-1-(1-methylcyclopropanecarbonyl)pyrrolidin-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / N,N-dimethyl-formamide; dichloromethane / 1.17 h / 2 - 20 °C

2.1: sodium 2-ethylhexanoic acid / water / 16 h / 50 °C

2.2: 20 °C

3.1: triethylamine; dmap / dichloromethane / 16 h / 20 °C

With dmap; triethylamine; sodium 2-ethylhexanoic acid; In dichloromethane; water; N,N-dimethyl-formamide;