1434818-32-2

Basic information

• Product Name: benzenesulfonic acid (3S,5S)-5-(1-cyanocyclopropylcarbamoyl)-1-(1-methylcyclopropanecarbonyl)pyrrolidin-3-yl ester
• Synonyms: benzenesulfonic acid (3S,5S)-5-(1-cyanocyclopropylcarbamoyl)-1-(1-methylcyclopropanecarbonyl)pyrrolidin-3-yl ester
• CAS NO: 1434818-32-2
• Molecular Weight: 417.486
• Mol File: 1434818-32-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: benzenesulfonic acid (3S,5S)-5-(1-cyanocyclopropylcarbamoyl)-1-(1-methylcyclopropanecarbonyl)pyrrolidin-3-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: benzenesulfonic acid (3S,5S)-5-(1-cyanocyclopropylcarbamoyl)-1-(1-methylcyclopropanecarbonyl)pyrrolidin-3-yl ester(1434818-32-2)
• EPA Substance Registry System: benzenesulfonic acid (3S,5S)-5-(1-cyanocyclopropylcarbamoyl)-1-(1-methylcyclopropanecarbonyl)pyrrolidin-3-yl ester(1434818-32-2)

Safety Data

• Hazardous Substances Data: 1434818-32-2(Hazardous Substances Data)

Upstream product

• 16480-05-0 1-methylcyclopropanecarbonyl chloride 
• 6914-76-7 1-Methyl-cyclopropanoic acid 
• 1434816-66-6 (2S,4S)-4-hydroxy-1-(1-methyl-cyclopropanecarbonyl)-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide 
• 98-09-9 benzenesulfonyl chloride 
• 87250-97-3 2’-methyl-2’-propanyl (1S,4S)-3-oxo-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate 
• 1434816-77-9 (2S,4R)-4-methanesulfonyloxy-1-(1-methylcyclopropanecarbonyl)pyrrolidine-2-carboxylic acid methyl ester 
• 1434816-54-2 (1S,4S)-5-(1-methyl cyclopropanecarbonyl)-2-oxa-5-aza-bicyclo[2.2.1]heptan-3-one 

Downstream Products

• 1252637-66-3 (2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2-methylpyridin-4-yl)-2-trifluoromethylbenzenesulfonyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide 
• 1434818-81-1 (2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2-methyl-pyridin-4-yl)-2-trifluoromethylphenylsulfanyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)-amide 
• 1434818-39-9 (2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2,2,2-trifluoroethoxy)-2-trifluoromethylphenylsulfanyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide 
• 1252637-07-2 (2S,4R)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2,2,2-trifluoroethoxy)-2-trifluoromethylbenzenesulfonyl]pyrrolidine-2-carboxylic acid (1-cyanocyclopropyl)amide 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF PROLINE DERIVATIVES

The present invention relates in part to a process for the preparation of a proline derivative of formula I wherein, R1 is C1-7-alkyl or wherein R4 is selected from the group consisting of C1-7-alkyl, halogen-C1-7-alkyl and phenyl optionally substituted by halogen; R2 is halogen or halogen-C1-7-alkyl; and R3 is selected from the group consisting of hydrogen, halogen, halogen-C1-7-alkyl, C1-7-alkoxy, halogen-C1-7-alkoxy and a 5- or 6-membered heterocyclic ring containing one or two nitrogen atoms, said ring being optionally substituted by C1-7-alkyl or halogen. The proline derivatives of the formula I are preferential inhibitors of the cysteine protease Cathepsin S and are therefore useful to treat metabolic diseases like diabetes, atherosclerosis, abdominal aortic aneurysm, peripheral arterial disease and diabetic nephropathy.