2-{8-(4-chloro-phenyl)-2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl}-propan-2-ol

Base Information

Chemical Name:2-{8-(4-chloro-phenyl)-2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl}-propan-2-ol
CAS No.:1319067-23-6
Molecular Formula:C₂₇H₂₇ClN₆O₂
Molecular Weight:503.003
Hs Code.:

Synonyms:2-{8-(4-chloro-phenyl)-2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl}-propan-2-ol

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Chemical Property of 2-{8-(4-chloro-phenyl)-2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl}-propan-2-ol

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Technology Process of 2-{8-(4-chloro-phenyl)-2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl}-propan-2-ol

There total 6 articles about 2-{8-(4-chloro-phenyl)-2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl}-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 958245-18-6
3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline

: 1319069-38-9
2-[2-bromo-8-(4-chloro-phenyl)-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-propan-2-ol

: 1319067-23-6
2-{8-(4-chloro-phenyl)-2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl}-propan-2-ol

Guidance literature:: With sodium phenoxide; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 160 ℃; for 15h; Inert atmosphere; Sealed tube;

Reference yield:

: 1319069-33-4
2-amino-8-bromo-6-methyl-[1,2,4]triazolo[1,5-a]pyridine-5-carboxylic acid methyl ester

: 1319067-23-6
2-{8-(4-chloro-phenyl)-2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl}-propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene; tetrahydrofuran / 3.5 h / -40 - -30 °C

1.2: 20 °C

2.1: sodium carbonate / 1,4-dioxane; water / 0.08 h / Inert atmosphere

2.2: 1.5 h / 80 °C

3.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 3 h / 60 °C

4.1: sodium phenoxide / 1,4-dioxane / 0.17 h / Inert atmosphere; Sealed tube

4.2: 15 h / 160 °C / Inert atmosphere; Sealed tube

With tert.-butylnitrite; sodium phenoxide; sodium carbonate; copper(ll) bromide; In tetrahydrofuran; 1,4-dioxane; water; toluene; acetonitrile;

Reference yield:

: 1319069-35-6
2-(2-amino-8-bromo-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-propan-2-ol

: 1319067-23-6
2-{8-(4-chloro-phenyl)-2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-yl}-propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / 1,4-dioxane; water / 0.08 h / Inert atmosphere

1.2: 1.5 h / 80 °C

2.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 3 h / 60 °C

3.1: sodium phenoxide / 1,4-dioxane / 0.17 h / Inert atmosphere; Sealed tube

3.2: 15 h / 160 °C / Inert atmosphere; Sealed tube

With tert.-butylnitrite; sodium phenoxide; sodium carbonate; copper(ll) bromide; In 1,4-dioxane; water; acetonitrile;