methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-3-pyrrolidinecarboxylate

Base Information

Chemical Name:methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-3-pyrrolidinecarboxylate
CAS No.:1301660-66-1
Molecular Formula:C₃₁H₂₈F₇N₃O₄
Molecular Weight:639.57
Hs Code.:

methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-3-pyrrolidinecarboxylate

Synonyms:methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-3-pyrrolidinecarboxylate

Suppliers and Price of methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-3-pyrrolidinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-3-pyrrolidinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-3-pyrrolidinecarboxylate

There total 8 articles about methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-3-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1301660-65-0
1-(1,1-dimethylethyl) 3-methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methyl-propanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1,3-pyrrolidinedicarboxylate

: 1301660-66-1
methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-3-pyrrolidinecarboxylate

Guidance literature:: 1-(1,1-dimethylethyl) 3-methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methyl-propanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1,3-pyrrolidinedicarboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In dichloromethane; water; Product distribution / selectivity;

Reference yield:

: 825643-73-0
2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide

: 1301660-66-1
methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-3-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 8 h / Reflux

2.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.5 h / 20 °C

2.2: 4 h / 20 °C

3.1: toluene / 2 h / Reflux

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0 - 20 °C

5.1: hydrogen / Raney-Ni / ethanol; water / 4 h

6.1: dmap; triethylamine / dichloromethane / 24 h / 20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 - 20 °C

7.2: 0.25 h / -78 °C

8.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With dmap; osmium(VIII) oxide; water; hydrogen; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; toluene; 1.1: Suzuki Coupling;

Reference yield:

: 1301660-58-1
ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-propenoate

: 1301660-66-1
methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-3-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0 - 20 °C

2.1: hydrogen / Raney-Ni / ethanol; water / 4 h

3.1: dmap; triethylamine / dichloromethane / 24 h / 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 - 20 °C

4.2: 0.25 h / -78 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With dmap; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; Raney-Ni; In tetrahydrofuran; ethanol; dichloromethane; water;