1-(1,1-dimethylethyl) 3-methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methyl-propanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1,3-pyrrolidinedicarboxylate

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Chemical Name:1-(1,1-dimethylethyl) 3-methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methyl-propanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1,3-pyrrolidinedicarboxylate
CAS No.:1301660-65-0
Molecular Formula:C₃₆H₃₆F₇N₃O₆
Molecular Weight:739.687
Hs Code.:

1-(1,1-dimethylethyl) 3-methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methyl-propanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1,3-pyrrolidinedicarboxylate

Synonyms:1-(1,1-dimethylethyl) 3-methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methyl-propanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1,3-pyrrolidinedicarboxylate

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Chemical Property of 1-(1,1-dimethylethyl) 3-methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methyl-propanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1,3-pyrrolidinedicarboxylate

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Technology Process of 1-(1,1-dimethylethyl) 3-methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methyl-propanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1,3-pyrrolidinedicarboxylate

There total 7 articles about 1-(1,1-dimethylethyl) 3-methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methyl-propanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1,3-pyrrolidinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1301660-62-7
1,1-dimethylethyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1-pyrrolidinecarboxylate

: 79-22-1
methyl chloroformate

: 1301660-65-0
1-(1,1-dimethylethyl) 3-methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methyl-propanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1,3-pyrrolidinedicarboxylate

Guidance literature:: 1,1-dimethylethyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1-pyrrolidinecarboxylate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; for 1.16667h;

methyl chloroformate; In tetrahydrofuran; at -78 ℃; for 0.25h;

Reference yield:

: 825643-73-0
2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide

: 1301660-65-0
1-(1,1-dimethylethyl) 3-methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methyl-propanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1,3-pyrrolidinedicarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 8 h / Reflux

2.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.5 h / 20 °C

2.2: 4 h / 20 °C

3.1: toluene / 2 h / Reflux

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0 - 20 °C

5.1: hydrogen / Raney-Ni / ethanol; water / 4 h

6.1: dmap; triethylamine / dichloromethane / 24 h / 20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 - 20 °C

7.2: 0.25 h / -78 °C

With dmap; osmium(VIII) oxide; water; hydrogen; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; toluene; 1.1: Suzuki Coupling;

Reference yield:

: 1301660-58-1
ethyl 3-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-propenoate

: 1301660-65-0
1-(1,1-dimethylethyl) 3-methyl 4-[5-[{2-[3,5-bis(trifluoromethyl)phenyl]-2-methyl-propanoyl}(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-2-oxo-1,3-pyrrolidinedicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0 - 20 °C

2.1: hydrogen / Raney-Ni / ethanol; water / 4 h

3.1: dmap; triethylamine / dichloromethane / 24 h / 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 - 20 °C

4.2: 0.25 h / -78 °C

With dmap; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hexamethyldisilazane; Raney-Ni; In tetrahydrofuran; ethanol; dichloromethane; water;