(S)-2-(2-(3-(benzyloxy)phenyl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyethyl pivalate

Base Information

• Chemical Name: (S)-2-(2-(3-(benzyloxy)phenyl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyethyl pivalate
• CAS No.: 1471256-45-7
• Molecular Formula: C₃₈H₄₀ClNO₄S
• Molecular Weight: 642.259
• Mol file: 1471256-45-7.mol

Synonyms:(S)-2-(2-(3-(benzyloxy)phenyl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyethyl pivalate

Chemical Property of (S)-2-(2-(3-(benzyloxy)phenyl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyethyl pivalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(2-(3-(benzyloxy)phenyl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyethyl pivalate

There total 11 articles about (S)-2-(2-(3-(benzyloxy)phenyl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyethyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(S)-2-(2-(3-(benzyloxy)phenyl)-7-bromo-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyethyl pivalate (1471256-44-6) + 4-Chlorophenylboronic acid (1679-18-1) → (S)-2-(2-(3-(benzyloxy)phenyl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyethyl pivalate (1471256-45-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; at 120 ℃; Sealed tube;

Reference yield:

2-methyl-4-nitrophenol (99-53-6) → (S)-2-(2-(3-(benzyloxy)phenyl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyethyl pivalate (1471256-45-7)

Guidance literature:

Multi-step reaction with 11 steps

1.1: bromine; acetic acid / 4 h / 20 °C

2.1: triethylamine / dichloromethane / 0.33 h / -70 °C

3.1: lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 3 h / 70 °C / Inert atmosphere

3.2: 0.17 h / 70 °C

4.1: methanesulfonamide; hydroquinine 1,4-phthalazinediyl diether / water; tert-butyl alcohol / 72 h / 0 °C

5.1: pyridine / dichloromethane / 5 h / 0 - 20 °C

6.1: perchloric acid / 1.5 h / 0 - 20 °C

7.1: platinum on activated charcoal; hydrogen / ethanol / 3 h / 20 °C

8.1: acetic acid / 0.5 h / 20 °C

8.2: 2 h / 20 °C

9.1: copper dichloride; tert.-butylnitrite / acetonitrile / 5 h / 20 °C

10.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 1.5 h / 95 °C / Sealed tube

11.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 120 °C / Sealed tube

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; perchloric acid; methanesulfonamide; hydroquinine 1,4-phthalazinediyl diether; platinum on activated charcoal; hydrogen; bromine; potassium carbonate; acetic acid; triethylamine; lithium chloride; copper dichloride; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

Reference yield:

2-bromo-6-methyl-4-nitrophenol (4186-49-6) → (S)-2-(2-(3-(benzyloxy)phenyl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyethyl pivalate (1471256-45-7)

Guidance literature:

Multi-step reaction with 10 steps

1.1: triethylamine / dichloromethane / 0.33 h / -70 °C

2.1: lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 3 h / 70 °C / Inert atmosphere

2.2: 0.17 h / 70 °C

3.1: methanesulfonamide; hydroquinine 1,4-phthalazinediyl diether / water; tert-butyl alcohol / 72 h / 0 °C

4.1: pyridine / dichloromethane / 5 h / 0 - 20 °C

5.1: perchloric acid / 1.5 h / 0 - 20 °C

6.1: platinum on activated charcoal; hydrogen / ethanol / 3 h / 20 °C

7.1: acetic acid / 0.5 h / 20 °C

7.2: 2 h / 20 °C

8.1: copper dichloride; tert.-butylnitrite / acetonitrile / 5 h / 20 °C

9.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 1.5 h / 95 °C / Sealed tube

10.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 120 °C / Sealed tube

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; perchloric acid; methanesulfonamide; hydroquinine 1,4-phthalazinediyl diether; platinum on activated charcoal; hydrogen; potassium carbonate; acetic acid; triethylamine; lithium chloride; copper dichloride; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;

upstream raw materials:

2-bromo-6-methyl-4-nitrophenol

2-methyl-4-nitrophenol

2-bromo-6-methyl-4-nitrophenyl trifluoromethanesulfonate

1-bromo-3-methyl-5-nitro-2-vinylbenzene

Downstream raw materials:

(S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(3-(5-methoxypyridin-3-yl)phenyl)-5-methylbenzo[d]thiazol-6-yl)acetic acid

(S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(3-(1,5-dimethyl-1H-pyrazol-4-yl)phenyl)-5-methylbenzo[d]thiazol-6-yl)acetic acid

(S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(3-(2-chloropyridin-4-yl)phenyl)-5-methylbenzo[d]thiazol-6-yl)ethyl pivalate

(S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(3-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)phenyl)benzo[d]thiazol-6-yl)ethanol