(R)-1-<1-hydroxy-2-(pivaloyloxy)ethyl>-2,4-dimethoxy-6-<<(tert-butyldimethylsilyl)oxy>methyl>benzene

Base Information

• Chemical Name: (R)-1-<1-hydroxy-2-(pivaloyloxy)ethyl>-2,4-dimethoxy-6-<<(tert-butyldimethylsilyl)oxy>methyl>benzene
• CAS No.: 173074-04-9
• Molecular Formula: C₂₂H₃₈O₆Si
• Molecular Weight: 426.626
• Mol file: 173074-04-9.mol

Synonyms:(R)-1-<1-hydroxy-2-(pivaloyloxy)ethyl>-2,4-dimethoxy-6-<<(tert-butyldimethylsilyl)oxy>methyl>benzene

Chemical Property of (R)-1-<1-hydroxy-2-(pivaloyloxy)ethyl>-2,4-dimethoxy-6-<<(tert-butyldimethylsilyl)oxy>methyl>benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-<1-hydroxy-2-(pivaloyloxy)ethyl>-2,4-dimethoxy-6-<<(tert-butyldimethylsilyl)oxy>methyl>benzene

There total 1 articles about (R)-1-<1-hydroxy-2-(pivaloyloxy)ethyl>-2,4-dimethoxy-6-<<(tert-butyldimethylsilyl)oxy>methyl>benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

pivaloyl chloride (3282-30-2) + 1-[2-(tert-Butyl-dimethyl-silanyloxymethyl)-4,6-dimethoxy-phenyl]-ethane-1,2-diol → (R)-1-<1-hydroxy-2-(pivaloyloxy)ethyl>-2,4-dimethoxy-6-<<(tert-butyldimethylsilyl)oxy>methyl>benzene (173074-04-9)

Guidance literature:

With dmap; In pyridine; at 0 ℃;

DOI:10.1021/jo9519367

Reference yield:

2-Methoxypropene (116-11-0) + (R)-1-<1-hydroxy-2-(pivaloyloxy)ethyl>-2,4-dimethoxy-6-<<(tert-butyldimethylsilyl)oxy>methyl>benzene (173074-04-9) → (R)-1-<1-<(2-methoxyprop-2-yl)oxy>-2-(pivaloyloxy)ethyl>-2,4-dimethoxy-6-<<(tert-butyldimethylsilyl)oxy>methyl>benzene (173074-05-0)

Guidance literature:

With pyridinium p-toluenesulfonate; In dichloromethane; at 0 ℃;

DOI:10.1021/jo9519367

Reference yield:

(R)-1-<1-hydroxy-2-(pivaloyloxy)ethyl>-2,4-dimethoxy-6-<<(tert-butyldimethylsilyl)oxy>methyl>benzene (173074-04-9) → (R)-1-<1-<(2-methoxyprop-2-yl)oxy>-2-hydroxyethyl>-2,4-dimethoxy-6-<<(tert-butyldimethylsilyl)oxy>methyl>benzene (173074-07-2)

Guidance literature:

Multi-step reaction with 2 steps

1: PPTS / CH₂Cl₂ / 0 °C

2: 96 percent / LiAlH₄ / diethyl ether / 0 °C

With lithium aluminium tetrahydride; pyridinium p-toluenesulfonate; In diethyl ether; dichloromethane;

DOI:10.1021/jo9519367

upstream raw materials:

pivaloyl chloride

Downstream raw materials:

(R)-1-<1-<(2-methoxyprop-2-yl)oxy>-2-(pivaloyloxy)ethyl>-2,4-dimethoxy-6-<<(tert-butyldimethylsilyl)oxy>methyl>benzene

(R)-1-<1-<(2-methoxyprop-2-yl)oxy>-2-hydroxyethyl>-2,4-dimethoxy-6-<<(tert-butyldimethylsilyl)oxy>methyl>benzene