(4-(5-(1-(4-(4-cyclohexylbenzyloxy)phenyl)methylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)fluoroacetic acid

Base Information

Chemical Name:(4-(5-(1-(4-(4-cyclohexylbenzyloxy)phenyl)methylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)fluoroacetic acid
CAS No.:1186633-85-1
Molecular Formula:C₃₂H₃₁FN₂O₄S
Molecular Weight:558.674
Hs Code.:

Synonyms:(4-(5-(1-(4-(4-cyclohexylbenzyloxy)phenyl)methylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)fluoroacetic acid

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Chemical Property of (4-(5-(1-(4-(4-cyclohexylbenzyloxy)phenyl)methylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)fluoroacetic acid

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Technology Process of (4-(5-(1-(4-(4-cyclohexylbenzyloxy)phenyl)methylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)fluoroacetic acid

There total 11 articles about (4-(5-(1-(4-(4-cyclohexylbenzyloxy)phenyl)methylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)fluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.4%

: 1186634-15-0
(4-(5-(1-(4-(4-cyclohexylbenzyloxy)phenyl)methylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)fluoroacetic acid ethyl ester

: 1186633-85-1
(4-(5-(1-(4-(4-cyclohexylbenzyloxy)phenyl)methylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)fluoroacetic acid

Guidance literature:: (4-(5-(1-(4-(4-cyclohexylbenzyloxy)phenyl)methylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)fluoroacetic acid ethyl ester; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=~ 4;

Reference yield:

: 121986-07-0,137766-69-9,13312-80-6
p-nitromandelonitrile

: 1186633-85-1
(4-(5-(1-(4-(4-cyclohexylbenzyloxy)phenyl)methylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)fluoroacetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride / water; acetic acid / 4 h / 100 °C

1.2: 4 h / 80 - 85 °C

2.1: hydrogen / palladium on activated charcoal / methanol / 4 h

3.1: ethanol / 6 h / Reflux

4.1: triethylamine / ethanol / 5 h / Reflux

5.1: diethylamino-sulfur trifluoride / dichloromethane / 1 h / 10 °C / Inert atmosphere

6.1: piperidine / ethanol / 20 h / Reflux

7.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

7.2: pH ~ 4

With piperidine; hydrogenchloride; diethylamino-sulfur trifluoride; water; hydrogen; triethylamine; lithium hydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetic acid;

Reference yield:

4-nitro-mandelic acid-ethyl ester: 13312-87-3
4-nitro-mandelic acid-ethyl ester

: 1186633-85-1
(4-(5-(1-(4-(4-cyclohexylbenzyloxy)phenyl)methylidene)-3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)fluoroacetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium on activated charcoal / methanol / 4 h

2.1: ethanol / 6 h / Reflux

3.1: triethylamine / ethanol / 5 h / Reflux

4.1: diethylamino-sulfur trifluoride / dichloromethane / 1 h / 10 °C / Inert atmosphere

5.1: piperidine / ethanol / 20 h / Reflux

6.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

6.2: pH ~ 4

With piperidine; diethylamino-sulfur trifluoride; water; hydrogen; triethylamine; lithium hydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;