4-nitro-mandelic acid-ethyl ester

Base Information

• Chemical Name: 4-nitro-mandelic acid-ethyl ester
• CAS No.: 13312-87-3
• Molecular Formula: C₁₀H₁₁NO₅
• Molecular Weight: 225.201
• Mol file: 13312-87-3.mol

Synonyms:4-nitro-mandelic acid-ethyl ester

Chemical Property of 4-nitro-mandelic acid-ethyl ester

Chemical Property:

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-nitro-mandelic acid-ethyl ester

There total 4 articles about 4-nitro-mandelic acid-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.1%

ethanol (64-17-5) + p-nitromandelonitrile (121986-07-0,137766-69-9,13312-80-6) → 4-nitro-mandelic acid-ethyl ester (13312-87-3)

Guidance literature:

p-nitromandelonitrile; With hydrogenchloride; In water; acetic acid; at 100 ℃; for 4h;

ethanol; With sulfuric acid; at 80 - 85 ℃; for 4h;

Reference yield:

4-nitrobenzaldehdye (555-16-8) → 4-nitro-mandelic acid-ethyl ester (13312-87-3)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid

2: alcoholic hydrochloric acid / Behandlung des entstandenen Iminoaetherhydrochlorids mit Wasser

With hydrogenchloride; acetic acid;

Reference yield:

p-nitromandelonitrile (121986-07-0,137766-69-9,13312-80-6) → 4-nitro-mandelic acid-ethyl ester (13312-87-3)

Guidance literature:

With hydrogenchloride; Behandlung des entstandenen Iminoaetherhydrochlorids mit Wasser;

upstream raw materials:

p-nitromandelonitrile

4-nitrobenzaldehdye

ethanol

Downstream raw materials:

ethyl 2-(4-aminophenyl)-2-hydroxyacetate

hydroxy(4-(3-methylthioureido)phenyl)acetic acid ethyl ester

hydroxy(4-(3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)acetic acid ethyl ester

fluoro(4-(3-methyl-4-oxothiazolidin-2-ylideneamino)phenyl)acetic acid ethyl ester