4-tert-butyl 6-ethyl 2-((S)-1-((tert-butyloxycarbonyl)(((S)-3-(tert-butyloxycarbonyl)-2,2-dimethyloxazolidin-4-yl)methyl)amino)-3-oxo-3-(tritylamino)propyl)-5-methylpyrimidine-4,6-dicarboxylate

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Chemical Name:4-tert-butyl 6-ethyl 2-((S)-1-((tert-butyloxycarbonyl)(((S)-3-(tert-butyloxycarbonyl)-2,2-dimethyloxazolidin-4-yl)methyl)amino)-3-oxo-3-(tritylamino)propyl)-5-methylpyrimidine-4,6-dicarboxylate
CAS No.:1542166-94-8
Molecular Formula:C₅₁H₆₅N₅O₁₀
Molecular Weight:908.105
Hs Code.:

4-tert-butyl 6-ethyl 2-((S)-1-((tert-butyloxycarbonyl)(((S)-3-(tert-butyloxycarbonyl)-2,2-dimethyloxazolidin-4-yl)methyl)amino)-3-oxo-3-(tritylamino)propyl)-5-methylpyrimidine-4,6-dicarboxylate

Synonyms:4-tert-butyl 6-ethyl 2-((S)-1-((tert-butyloxycarbonyl)(((S)-3-(tert-butyloxycarbonyl)-2,2-dimethyloxazolidin-4-yl)methyl)amino)-3-oxo-3-(tritylamino)propyl)-5-methylpyrimidine-4,6-dicarboxylate

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Chemical Property of 4-tert-butyl 6-ethyl 2-((S)-1-((tert-butyloxycarbonyl)(((S)-3-(tert-butyloxycarbonyl)-2,2-dimethyloxazolidin-4-yl)methyl)amino)-3-oxo-3-(tritylamino)propyl)-5-methylpyrimidine-4,6-dicarboxylate

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Technology Process of 4-tert-butyl 6-ethyl 2-((S)-1-((tert-butyloxycarbonyl)(((S)-3-(tert-butyloxycarbonyl)-2,2-dimethyloxazolidin-4-yl)methyl)amino)-3-oxo-3-(tritylamino)propyl)-5-methylpyrimidine-4,6-dicarboxylate

There total 10 articles about 4-tert-butyl 6-ethyl 2-((S)-1-((tert-butyloxycarbonyl)(((S)-3-(tert-butyloxycarbonyl)-2,2-dimethyloxazolidin-4-yl)methyl)amino)-3-oxo-3-(tritylamino)propyl)-5-methylpyrimidine-4,6-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1542166-93-7
4-tert-butyl 6-ethyl 2-((S)-1-((((S)-3-(tert-butyloxycarbonyl)-2,2-dimethyloxazolidin-4-yl)methyl)amino)-3-oxo-3-(tritylamino)propyl)-5-methylpyrimidine-4,6-dicarboxylate

: 1542166-94-8
4-tert-butyl 6-ethyl 2-((S)-1-((tert-butyloxycarbonyl)(((S)-3-(tert-butyloxycarbonyl)-2,2-dimethyloxazolidin-4-yl)methyl)amino)-3-oxo-3-(tritylamino)propyl)-5-methylpyrimidine-4,6-dicarboxylate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 50 ℃; for 12h;
DOI:10.1021/ja412298c

Reference yield:

: 1542166-88-0
3-(tert-butyl) 5-ethyl 1-amino-4-methyl-1H-pyrazole-3,5-dicarboxylate

: 1542166-94-8
4-tert-butyl 6-ethyl 2-((S)-1-((tert-butyloxycarbonyl)(((S)-3-(tert-butyloxycarbonyl)-2,2-dimethyloxazolidin-4-yl)methyl)amino)-3-oxo-3-(tritylamino)propyl)-5-methylpyrimidine-4,6-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydrogencarbonate; iodine / water; dichloromethane / 2 h / 25 °C

2: acetonitrile / 15 h / 25 °C / Molecular sieve

3: triethylamine / tetrahydrofuran / 12 h / 50 °C

With iodine; potassium hydrogencarbonate; triethylamine; In tetrahydrofuran; dichloromethane; water; acetonitrile; 2: |Diels-Alder Cycloaddition;
DOI:10.1021/ja412298c

Reference yield:

: 3246-27-3
tert-butyl crotonate

: 1542166-94-8
4-tert-butyl 6-ethyl 2-((S)-1-((tert-butyloxycarbonyl)(((S)-3-(tert-butyloxycarbonyl)-2,2-dimethyloxazolidin-4-yl)methyl)amino)-3-oxo-3-(tritylamino)propyl)-5-methylpyrimidine-4,6-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide

2.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 0.5 h / 20 °C

2.2: 0.5 h / 25 °C

3.1: silver nitrate; [bis(acetoxy)iodo]benzene / water; dichloromethane / 2 h / 25 °C

4.1: acetonitrile / 15 h / 25 °C / Molecular sieve

5.1: triethylamine / tetrahydrofuran / 12 h / 50 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; [bis(acetoxy)iodo]benzene; potassium tert-butylate; silver nitrate; triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 4.1: |Diels-Alder Cycloaddition;
DOI:10.1021/ja412298c