6-amino-3-methyl-1-phenyl-4-(pyridin-4-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

Base Information

• Chemical Name: 6-amino-3-methyl-1-phenyl-4-(pyridin-4-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
• CAS No.: 106753-80-4
• Molecular Formula: C₁₉H₁₅N₅O
• Molecular Weight: 329.361
• Mol file: 106753-80-4.mol

Synonyms:6-amino-3-methyl-1-phenyl-4-(pyridin-4-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

Chemical Property of 6-amino-3-methyl-1-phenyl-4-(pyridin-4-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 6-amino-3-methyl-1-phenyl-4-(pyridin-4-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

There total 3 articles about 6-amino-3-methyl-1-phenyl-4-(pyridin-4-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

pyridine-4-carbaldehyde (872-85-5) + edaravone (89-25-8) + malononitrile (109-77-3) → 6-amino-3-methyl-1-phenyl-4-(pyridin-4-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile (106753-80-4)

Guidance literature:

With BF₃ bonded nano Fe₃O₄-450; In ethanol; at 80 ℃; for 1h;

DOI:10.1039/c5ra11343a

Reference yield: 88.0%

pyridine-4-carbaldehyde (872-85-5) + ethyl acetoacetate (141-97-9) + phenylhydrazine (100-63-0) + malononitrile (109-77-3) → 6-amino-3-methyl-1-phenyl-4-(pyridin-4-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile (106753-80-4)

Guidance literature:

With 1-methylimidazolium trinitromethanide; In neat (no solvent); at 25 ℃; for 0.5h; Green chemistry;

DOI:10.1039/c5ra16289k

Reference yield: 85.0%

4-pyridinylmethylenepropanedinitrile (63080-75-1) + edaravone (89-25-8) → 6-amino-3-methyl-1-phenyl-4-(pyridin-4-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile (106753-80-4)

Guidance literature:

With triethylamine; In ethanol; Heating;

upstream raw materials:

4-pyridinylmethylenepropanedinitrile

edaravone

pyridine-4-carbaldehyde

malononitrile