[1-(tert-butyl-dimethyl-silanyloxymethyl)-1-(3,4-dimethoxy-benzyloxymethyl)-5,5-dimethyl-4-oxo-hex-2-ynyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[1-(tert-butyl-dimethyl-silanyloxymethyl)-1-(3,4-dimethoxy-benzyloxymethyl)-5,5-dimethyl-4-oxo-hex-2-ynyl]-carbamic acid tert-butyl ester
CAS No.:618440-81-6
Molecular Formula:C₃₀H₄₉NO₇Si
Molecular Weight:563.807
Hs Code.:

[1-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-1-(3,4-dimethoxy-benzyloxymethyl)-5,5-dimethyl-4-oxo-hex-2-ynyl]-carbamic acid <i>tert</i>-butyl ester

Synonyms:[1-(tert-butyl-dimethyl-silanyloxymethyl)-1-(3,4-dimethoxy-benzyloxymethyl)-5,5-dimethyl-4-oxo-hex-2-ynyl]-carbamic acid tert-butyl ester

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Chemical Property of [1-(tert-butyl-dimethyl-silanyloxymethyl)-1-(3,4-dimethoxy-benzyloxymethyl)-5,5-dimethyl-4-oxo-hex-2-ynyl]-carbamic acid tert-butyl ester

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Technology Process of [1-(tert-butyl-dimethyl-silanyloxymethyl)-1-(3,4-dimethoxy-benzyloxymethyl)-5,5-dimethyl-4-oxo-hex-2-ynyl]-carbamic acid tert-butyl ester

There total 1 articles about [1-(tert-butyl-dimethyl-silanyloxymethyl)-1-(3,4-dimethoxy-benzyloxymethyl)-5,5-dimethyl-4-oxo-hex-2-ynyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 3282-30-2
pivaloyl chloride

: 502183-37-1
(S)-[1-(tert-butyldimethylsilanyloxymethyl)-1-(3,4-dimethoxybenzyloxymethyl)prop-2-ynyl]carbamic acid tert-butyl ester

: 618440-81-6
[1-(tert-butyl-dimethyl-silanyloxymethyl)-1-(3,4-dimethoxy-benzyloxymethyl)-5,5-dimethyl-4-oxo-hex-2-ynyl]-carbamic acid tert-butyl ester

Guidance literature:: With copper(l) iodide; triethylamine; In toluene; at 60 ℃; for 2h;
DOI:10.1021/ol034984j

Reference yield:

: 618440-81-6
[1-(tert-butyl-dimethyl-silanyloxymethyl)-1-(3,4-dimethoxy-benzyloxymethyl)-5,5-dimethyl-4-oxo-hex-2-ynyl]-carbamic acid tert-butyl ester

: [1-(tert-butyl-dimethyl-silanyloxymethyl)-1-(3,4-dimethoxy-benzyloxymethyl)-5,5-dimethyl-4-oxo-hexyl]-carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In benzene; for 12h; under 760 Torr;
DOI:10.1021/ol034984j

Reference yield:

: 618440-81-6
[1-(tert-butyl-dimethyl-silanyloxymethyl)-1-(3,4-dimethoxy-benzyloxymethyl)-5,5-dimethyl-4-oxo-hex-2-ynyl]-carbamic acid tert-butyl ester

: 2-tert-butoxycarbonylamino-2-(3,4-dimethoxy-benzyloxymethyl)-6,6-dimethyl-5-oxo-heptanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C / benzene / 12 h / 760 Torr

2: Bu₄NF / tetrahydrofuran; hexane / 6 h / 20 °C

3: 53 mg / Dess-Martin periodinane / CH₂Cl₂ / 12 h / 20 °C

4: NaH₂PO₄; 2-methyl-2-butene; NaClO₂ / 2-methyl-propan-2-ol; H₂O; tetrahydrofuran

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; tetrabutyl ammonium fluoride; hydrogen; Dess-Martin periodane; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; water; tert-butyl alcohol; benzene; 3: Dess-Martin oxidation;
DOI:10.1021/ol034984j