2-(cyclopropyl(3-iodo-5-nitropyridin-2-yl)amino)-N-(4-methoxybenzyl)-4-methylpentanamide

Base Information

• Chemical Name: 2-(cyclopropyl(3-iodo-5-nitropyridin-2-yl)amino)-N-(4-methoxybenzyl)-4-methylpentanamide
• CAS No.: 1372134-69-4
• Molecular Formula: C₂₂H₂₇IN₄O₄
• Molecular Weight: 538.385
• Mol file: 1372134-69-4.mol

Synonyms:2-(cyclopropyl(3-iodo-5-nitropyridin-2-yl)amino)-N-(4-methoxybenzyl)-4-methylpentanamide

Chemical Property of 2-(cyclopropyl(3-iodo-5-nitropyridin-2-yl)amino)-N-(4-methoxybenzyl)-4-methylpentanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(cyclopropyl(3-iodo-5-nitropyridin-2-yl)amino)-N-(4-methoxybenzyl)-4-methylpentanamide

There total 1 articles about 2-(cyclopropyl(3-iodo-5-nitropyridin-2-yl)amino)-N-(4-methoxybenzyl)-4-methylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

2-hydroxy-3-iodo-5-nitropyridine (25391-58-6) + 1-(isocyanomethyl)-4-methoxybenzene (1197-58-6) + Cyclopropylamine (765-30-0) + isovaleraldehyde (590-86-3) → 2-(cyclopropyl(3-iodo-5-nitropyridin-2-yl)amino)-N-(4-methoxybenzyl)-4-methylpentanamide (1372134-69-4)

Guidance literature:

In toluene; at 110 ℃; for 4h; Inert atmosphere;

DOI:10.1055/s-0031-1290312

Reference yield: 100.0%

2-(cyclopropyl(3-iodo-5-nitropyridin-2-yl)amino)-N-(4-methoxybenzyl)-4-methylpentanamide (1372134-69-4) → N-(4-methoxybenzyl)-4-methyl-2-(6-nitro-1,8-naphthyridin-1(4H)-yl)pentanamide (1372134-76-3)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 130 ℃; for 0.333333h; under 9750.98 Torr; Microwave irradiation;

DOI:10.1055/s-0031-1290312

upstream raw materials:

2-hydroxy-3-iodo-5-nitropyridine

1-(isocyanomethyl)-4-methoxybenzene

Cyclopropylamine

isovaleraldehyde

Downstream raw materials:

N-(4-methoxybenzyl)-4-methyl-2-(6-nitro-1,8-naphthyridin-1(4H)-yl)pentanamide