Technology Process of 2-(3,5-dichlorophenyl)-4-(3-piperidinemethyl)-thieno[2,3-d]pyridazine-7-carboxylic acid amide hydrochloride
There total 8 articles about 2-(3,5-dichlorophenyl)-4-(3-piperidinemethyl)-thieno[2,3-d]pyridazine-7-carboxylic acid amide hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sulfuric acid / Reflux
2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / ethanol; water; toluene / 3 h / Reflux
3.1: tetrahydrofuran / 20 °C
3.2: -78 °C
3.3: pH 3
4.1: hydrazine hydrate / ethanol / 20 - 70 °C
5.1: trichlorophosphate / 3 h / 90 °C
6.1: iron(III) chloride; diethylzinc / copper(l) chloride / 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 0.75 h / 40 - 45 °C
6.2: 4 h / 45 °C
7.1: ammonium hydroxide / 1,4-dioxane / 80 °C
8.1: hydrogenchloride; ethyl acetate / water / 1 h / 30 °C
With
hydrogenchloride; iron(III) chloride; ammonium hydroxide; hydrazine hydrate; sulfuric acid; diethylzinc; sodium carbonate; ethyl acetate; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0); copper(l) chloride;
In
tetrahydrofuran; 1,4-dioxane; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; ethanol; water; toluene;
- Guidance literature:
-
With
hydrogenchloride; ethyl acetate;
In
water;
at 30 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / ethanol; water; toluene / 3 h / Reflux
2.1: tetrahydrofuran / 20 °C
2.2: -78 °C
2.3: pH 3
3.1: hydrazine hydrate / ethanol / 20 - 70 °C
4.1: trichlorophosphate / 3 h / 90 °C
5.1: iron(III) chloride; diethylzinc / copper(l) chloride / 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 0.75 h / 40 - 45 °C
5.2: 4 h / 45 °C
6.1: ammonium hydroxide / 1,4-dioxane / 80 °C
7.1: hydrogenchloride; ethyl acetate / water / 1 h / 30 °C
With
hydrogenchloride; iron(III) chloride; ammonium hydroxide; hydrazine hydrate; diethylzinc; sodium carbonate; ethyl acetate; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0); copper(l) chloride;
In
tetrahydrofuran; 1,4-dioxane; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; ethanol; water; toluene;
