5-((2,6-diphenyl-4H-pyran-4-ylidene)methyl)-3,4-dihexylthiophene-2-carbaldehyde

Base Information

Chemical Name:5-((2,6-diphenyl-4H-pyran-4-ylidene)methyl)-3,4-dihexylthiophene-2-carbaldehyde
CAS No.:1354569-60-0
Molecular Formula:C₃₅H₄₀O₂S
Molecular Weight:524.767
Hs Code.:

Synonyms:5-((2,6-diphenyl-4H-pyran-4-ylidene)methyl)-3,4-dihexylthiophene-2-carbaldehyde

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Chemical Property of 5-((2,6-diphenyl-4H-pyran-4-ylidene)methyl)-3,4-dihexylthiophene-2-carbaldehyde

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Technology Process of 5-((2,6-diphenyl-4H-pyran-4-ylidene)methyl)-3,4-dihexylthiophene-2-carbaldehyde

There total 3 articles about 5-((2,6-diphenyl-4H-pyran-4-ylidene)methyl)-3,4-dihexylthiophene-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 618439-05-7
3,4-dihexylthiophene-2,5-dicarboxaldehyde

: 129806-51-5
2,6-diphenyl-(4H-pyran-4ylidene)-diphenylphosphine oxide

: 1354569-60-0
5-((2,6-diphenyl-4H-pyran-4-ylidene)methyl)-3,4-dihexylthiophene-2-carbaldehyde

Guidance literature:: 2,6-diphenyl-(4H-pyran-4ylidene)-diphenylphosphine oxide; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 ℃; for 0.25h; Inert atmosphere;

3,4-dihexylthiophene-2,5-dicarboxaldehyde; In tetrahydrofuran; hexanes; at -78 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol203298r

Reference yield:

: 122107-04-4
3,4-di-n-hexylthiophene

: 1354569-60-0
5-((2,6-diphenyl-4H-pyran-4-ylidene)methyl)-3,4-dihexylthiophene-2-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / hexane / 0.5 h / Reflux; Inert atmosphere

1.2: -40 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexanes / 0.25 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexanes; hexane; 2.2: Wittig-Horner reaction;
DOI:10.1021/ol203298r

Reference yield:

: 3761-92-0
n-hexylmagnesium bromide

: 1354569-60-0
5-((2,6-diphenyl-4H-pyran-4-ylidene)methyl)-3,4-dihexylthiophene-2-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) / diethyl ether / 20 h / 0 °C / Inert atmosphere; Reflux

2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / hexane / 0.5 h / Reflux; Inert atmosphere

2.2: -40 - 20 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexanes / 0.25 h / -78 °C / Inert atmosphere

3.2: 1 h / -78 °C / Inert atmosphere

With n-butyllithium; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexanes; diethyl ether; hexane; 3.2: Wittig-Horner reaction;
DOI:10.1021/ol203298r