3-(5-((2,6-diphenyl-4H-pyran-4-ylidene)methyl)-3,4-dihexylthiophen-2-yl)-2-cyanoacrylic acid

Base Information

Chemical Name:3-(5-((2,6-diphenyl-4H-pyran-4-ylidene)methyl)-3,4-dihexylthiophen-2-yl)-2-cyanoacrylic acid
CAS No.:1354569-68-8
Molecular Formula:C₃₈H₄₁NO₃S
Molecular Weight:591.814
Hs Code.:

Synonyms:3-(5-((2,6-diphenyl-4H-pyran-4-ylidene)methyl)-3,4-dihexylthiophen-2-yl)-2-cyanoacrylic acid

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Chemical Property of 3-(5-((2,6-diphenyl-4H-pyran-4-ylidene)methyl)-3,4-dihexylthiophen-2-yl)-2-cyanoacrylic acid

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Technology Process of 3-(5-((2,6-diphenyl-4H-pyran-4-ylidene)methyl)-3,4-dihexylthiophen-2-yl)-2-cyanoacrylic acid

There total 4 articles about 3-(5-((2,6-diphenyl-4H-pyran-4-ylidene)methyl)-3,4-dihexylthiophen-2-yl)-2-cyanoacrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1354569-60-0
5-((2,6-diphenyl-4H-pyran-4-ylidene)methyl)-3,4-dihexylthiophene-2-carbaldehyde

: 372-09-8
cyanoacetic acid

: 1354569-68-8
3-(5-((2,6-diphenyl-4H-pyran-4-ylidene)methyl)-3,4-dihexylthiophen-2-yl)-2-cyanoacrylic acid

Guidance literature:: With piperidine; In acetonitrile; for 24h; Reflux; Inert atmosphere;
DOI:10.1021/ol203298r

Reference yield:

: 618439-05-7
3,4-dihexylthiophene-2,5-dicarboxaldehyde

: 1354569-68-8
3-(5-((2,6-diphenyl-4H-pyran-4-ylidene)methyl)-3,4-dihexylthiophen-2-yl)-2-cyanoacrylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 0.25 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: piperidine / acetonitrile / 24 h / Reflux; Inert atmosphere

With piperidine; n-butyllithium; In tetrahydrofuran; hexanes; acetonitrile; 1.2: Wittig-Horner reaction / 2.1: Knoevenagel condensation;
DOI:10.1021/ol203298r

Reference yield:

: 3761-92-0
n-hexylmagnesium bromide

: 1354569-68-8
3-(5-((2,6-diphenyl-4H-pyran-4-ylidene)methyl)-3,4-dihexylthiophen-2-yl)-2-cyanoacrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) / diethyl ether / 20 h / 0 °C / Inert atmosphere; Reflux

2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / hexane / 0.5 h / Reflux; Inert atmosphere

2.2: -40 - 20 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexanes / 0.25 h / -78 °C / Inert atmosphere

3.2: 1 h / -78 °C / Inert atmosphere

4.1: piperidine / acetonitrile / 24 h / Reflux; Inert atmosphere

With piperidine; n-butyllithium; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexanes; diethyl ether; hexane; acetonitrile; 3.2: Wittig-Horner reaction / 4.1: Knoevenagel condensation;
DOI:10.1021/ol203298r