dimethyl 4-(4-(2-chloroquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

Chemical Name:dimethyl 4-(4-(2-chloroquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:1424371-15-2
Molecular Formula:C₂₆H₂₃ClN₂O₅
Molecular Weight:478.932
Hs Code.:

Synonyms:dimethyl 4-(4-(2-chloroquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

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Chemical Property of dimethyl 4-(4-(2-chloroquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

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Technology Process of dimethyl 4-(4-(2-chloroquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

There total 4 articles about dimethyl 4-(4-(2-chloroquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 703-61-7
2,4-dichloroquinoline

: 156304-06-2
dimethyl 4-(4-hydroxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

: 1424371-15-2
dimethyl 4-(4-(2-chloroquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 48h; regioselective reaction;
DOI:10.1007/s11164-013-1085-4

Reference yield:

: 105-45-3
acetoacetic acid methyl ester

: 1424371-15-2
dimethyl 4-(4-(2-chloroquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate / ethanol

2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 70 °C

With ammonium acetate; potassium carbonate; In ethanol; N,N-dimethyl-formamide; 1: |Hantzsch Dihydropyridine Synthesis;
DOI:10.1007/s11164-013-1085-4

Reference yield:

: 62-53-3
aniline

: 1424371-15-2
dimethyl 4-(4-(2-chloroquinolin-4-yloxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 5 h

2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 70 °C

With potassium carbonate; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1007/s11164-013-1085-4