C₁₇H₁₆ClNO₂S₂

Base Information

• Chemical Name: C₁₇H₁₆ClNO₂S₂
• CAS No.: 882278-95-7
• Molecular Formula: C₁₇H₁₆ClNO₂S₂
• Molecular Weight: 365.905
• Mol file: 882278-95-7.mol

Synonyms:C₁₇H₁₆ClNO₂S₂

Chemical Property of C₁₇H₁₆ClNO₂S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₁₆ClNO₂S₂

There total 4 articles about C₁₇H₁₆ClNO₂S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(4-chlorobenzoyl)-3,3-bis(isopropylthio)acrylonitrile (1191249-14-5) + ethyl 2-sulfanylacetate (623-51-8) → C17H16ClNO2S2 (882278-95-7)

Guidance literature:

With triethylamine; In ethanol; at 20 ℃;

DOI:10.1021/jm901280q

Reference yield: 91.0%

ethyl 3-bromo-4-cyano-5-(isopropylthio)thiophene-2-carboxylate (1421348-01-7) + 4-Chlorophenylboronic acid (1679-18-1) → C17H16ClNO2S2 (882278-95-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; water; toluene; for 4h; Reflux;

DOI:10.3109/14756366.2011.643302

Reference yield:

2-(bis(isopropylthio)methylene)malononitrile (1334294-79-9) → C17H16ClNO2S2 (882278-95-7)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / ethanol / 3 h / Reflux

2: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 0.17 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene; water / 4 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; potassium carbonate; copper(ll) bromide; In ethanol; water; toluene; acetonitrile; 2: |Sandmeyer Reaction / 3: |Suzuki-Miyaura Coupling;

DOI:10.3109/14756366.2011.643302

upstream raw materials:

2-(4-chlorobenzoyl)-3,3-bis(isopropylthio)acrylonitrile

ethyl 2-sulfanylacetate

ethyl 3-bromo-4-cyano-5-(isopropylthio)thiophene-2-carboxylate

4-Chlorophenylboronic acid

Downstream raw materials:

4-(4-chlorophenyl)-5-(hydroxymethyl)-2-(isopropylthio)thiophene-3-carbonitrile

C₁₅H₁₂ClNO₂S₂

3-(4-chlorophenyl)-4-cyano-5-(isopropylthio)-N-methoxy-N-methylthiophene-2-carboxamide

ethyl 4-(4-chlorophenyl)-3-cyano-2,3'-bithiophene-5-carboxylate