4-[(1-benzyl-2-indolyl)carbonylmethyl]-3-[(E)-2-(methoxycarbonyl)vinyl]-1-methyl-5-(trichloroacetyl)-1,4-dihydropyridine

Base Information

• Chemical Name: 4-[(1-benzyl-2-indolyl)carbonylmethyl]-3-[(E)-2-(methoxycarbonyl)vinyl]-1-methyl-5-(trichloroacetyl)-1,4-dihydropyridine
• CAS No.: 321526-01-6
• Molecular Formula: C₂₉H₂₅Cl₃N₂O₄
• Molecular Weight: 571.887

Synonyms:4-[(1-benzyl-2-indolyl)carbonylmethyl]-3-[(E)-2-(methoxycarbonyl)vinyl]-1-methyl-5-(trichloroacetyl)-1,4-dihydropyridine

Chemical Property of 4-[(1-benzyl-2-indolyl)carbonylmethyl]-3-[(E)-2-(methoxycarbonyl)vinyl]-1-methyl-5-(trichloroacetyl)-1,4-dihydropyridine

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Technology Process of 4-[(1-benzyl-2-indolyl)carbonylmethyl]-3-[(E)-2-(methoxycarbonyl)vinyl]-1-methyl-5-(trichloroacetyl)-1,4-dihydropyridine

There total 1 articles about 4-[(1-benzyl-2-indolyl)carbonylmethyl]-3-[(E)-2-(methoxycarbonyl)vinyl]-1-methyl-5-(trichloroacetyl)-1,4-dihydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

3-<2-(methoxycarbonyl)vinyl>piridinium iodide (119219-77-1) + 1-(1-benzyl-1H-indol-2-yl)ethan-1-one (95306-87-9) + trichloroacetic acid anhydride (4124-31-6) → 2-[(1-benzyl-2-indolyl)carbonylmethyl]-5-[(E)-2-(methoxycarbonyl)vinyl]-1-methyl-3-(trichloroacetyl)-1,2-dihydropyridine + 4-[(1-benzyl-2-indolyl)carbonylmethyl]-3-[(E)-2-(methoxycarbonyl)vinyl]-1-methyl-5-(trichloroacetyl)-1,4-dihydropyridine (321526-01-6)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃; for 3h;

DOI:10.1002/1099-0690(200012)2000:23<3919::AID-EJOC3919>3.0.CO;2-P

Reference yield: 85.0%

sodium methylate (124-41-4) + 4-[(1-benzyl-2-indolyl)carbonylmethyl]-3-[(E)-2-(methoxycarbonyl)vinyl]-1-methyl-5-(trichloroacetyl)-1,4-dihydropyridine (321526-01-6) → methyl 4-[(1-benzyl-2-indolyl)carbonylmethyl]-5-[(E)-2-(methoxycarbonyl)vinyl]-1-methyl-1,4-dihydropyridine-3-carboxylate

Guidance literature:

In tetrahydrofuran; methanol; at 20 ℃; for 0.05h;

DOI:10.1002/1099-0690(200012)2000:23<3919::AID-EJOC3919>3.0.CO;2-P

Reference yield: 85.0%

methanol (67-56-1) + 4-[(1-benzyl-2-indolyl)carbonylmethyl]-3-[(E)-2-(methoxycarbonyl)vinyl]-1-methyl-5-(trichloroacetyl)-1,4-dihydropyridine (321526-01-6) → methyl 4-[(1-benzyl-2-indolyl)carbonylmethyl]-5-[(E)-2-(methoxycarbonyl)vinyl]-1-methyl-1,4-dihydropyridine-3-carboxylate

Guidance literature:

With sodium methylate; for 0.05h; Ambient temperature;

DOI:10.1039/CC9960002755

upstream raw materials:

3-<2-(methoxycarbonyl)vinyl>piridinium iodide

1-(1-benzyl-1H-indol-2-yl)ethan-1-one

trichloroacetic acid anhydride

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