diphenyl 1-[(N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-(4-(N,N'-bis(tert-butyloxycarbonyl)guanidino)phenyl)ethanephosphonate

Base Information

Chemical Name:diphenyl 1-[(N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-(4-(N,N'-bis(tert-butyloxycarbonyl)guanidino)phenyl)ethanephosphonate
CAS No.:695172-16-8
Molecular Formula:C₄₉H₆₃N₆O₁₂P
Molecular Weight:959.046
Hs Code.:

diphenyl 1-[(N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-(4-(N,N'-bis(tert-butyloxycarbonyl)guanidino)phenyl)ethanephosphonate

Synonyms:diphenyl 1-[(N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-(4-(N,N'-bis(tert-butyloxycarbonyl)guanidino)phenyl)ethanephosphonate

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Chemical Property of diphenyl 1-[(N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-(4-(N,N'-bis(tert-butyloxycarbonyl)guanidino)phenyl)ethanephosphonate

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Technology Process of diphenyl 1-[(N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-(4-(N,N'-bis(tert-butyloxycarbonyl)guanidino)phenyl)ethanephosphonate

There total 20 articles about diphenyl 1-[(N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-(4-(N,N'-bis(tert-butyloxycarbonyl)guanidino)phenyl)ethanephosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 65806-90-8
(R)-2-(((benzyloxy)carbonyl)amino)-3-(tert-butoxy)propanoic acid

: C₃₄H₄₄N₅O₈P

: 695172-16-8
diphenyl 1-(((N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl)amino)-2-(4-(N,N'-bis(tert-butyloxycarbonyl)guanyl)phenyl)ethanephosphonate

Guidance literature:: (R)-2-(((benzyloxy)carbonyl)amino)-3-(tert-butoxy)propanoic acid; With TEA; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

C₃₄H₄₄N₅O₈P; In N,N-dimethyl-formamide;
DOI:10.1021/jm0499209

Reference yield: 52.0%

: 913239-32-4
[(N-benzyloxycarbonyl-O-tert-butyl)-D-seryl]-L-alanine

: 913239-29-9
diphenyl 1-amino-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate

: 695172-16-8
diphenyl 1-[(N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-(4-(N,N'-bis(tert-butyloxycarbonyl)guanidino)phenyl)ethanephosphonate

Guidance literature:: [(N-benzyloxycarbonyl-O-tert-butyl)-D-seryl]-L-alanine; With PS-carbodiimide; benzotriazol-1-ol; In dichloromethane; for 0.166667h;

diphenyl 1-amino-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate; In dichloromethane; at 20 ℃;
DOI:10.1021/jm060622g

Reference yield:

: 695172-02-2
diphenyl 1-(benzyloxycarbonylamino)-2-{4-[N,N'-bis(tert-butyloxycarbonyl)guanidino]phenyl}ethanephosphonate

: 695172-16-8
diphenyl 1-[(N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl]amino-2-(4-(N,N'-bis(tert-butyloxycarbonyl)guanidino)phenyl)ethanephosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: H₂ / Pd/C / methanol / 8 h / 20 °C

2.1: HOBt; PS-carbodiimide / CH₂Cl₂ / 0.17 h

2.2: 52 percent / CH₂Cl₂ / 20 °C

With PS-carbodiimide; hydrogen; benzotriazol-1-ol; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jm060622g